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Titolo:
The association between intravenous haloperidol and prolonged QT interval
Autore:
Hatta, K; Takahashi, T; Nakamura, H; Yamashiro, H; Asukai, N; Matsuzaki, I; Yonezawa, Y;
Indirizzi:
Tokyo Metropolitan Bokuto Gen Hosp, Dept Psychiat, Tokyo, Japan Tokyo Metropolitan Bokuto Gen Hosp Tokyo Japan t Psychiat, Tokyo, Japan Kanazawa Univ, Sch Med, Dept Publ Hlth, Kanazawa, Ishikawa 920, Japan Kanazawa Univ Kanazawa Ishikawa Japan 920 , Kanazawa, Ishikawa 920, Japan Tokyo Inst Psychiat, Dept Social Psychiat, Tokyo, Japan Tokyo Inst Psychiat Tokyo Japan iat, Dept Social Psychiat, Tokyo, Japan Univ Tsukuba, Inst Community Med, Tsukuba, Ibaraki 305, Japan Univ Tsukuba Tsukuba Ibaraki Japan 305 y Med, Tsukuba, Ibaraki 305, Japan
Titolo Testata:
JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY
fascicolo: 3, volume: 21, anno: 2001,
pagine: 257 - 261
SICI:
0271-0749(200106)21:3<257:TABIHA>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
TORSADES-DE-POINTES; HYPOKALEMIA; ILL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
13
Recensione:
Indirizzi per estratti:
Indirizzo: Hatta, K Kitasato Univ, Sch Med, Dept Psychiat, Kitasato 1-15-1, Sagamihara, Kanagawa 2288555, Japan Kitasato Univ Kitasato 1-15-1 Sagamihara Kanagawa Japan 2288555 n
Citazione:
K. Hatta et al., "The association between intravenous haloperidol and prolonged QT interval", J CL PSYCH, 21(3), 2001, pp. 257-261

Abstract

Although intravenous haloperidol (HAL) is an effective medication that is often prescribed to treat agitation, several instances of torsade de pointes or prolonged QT interval have been reported. To investigate the association between intravenous HAL and QT prolongation and between intravenous HAL and ventricular tachyarrhythmia, a cross-sectional cohort study was performed that included measuring corrected QT intervals (QTc) on an emergency basis before intravenous HAL and continuously monitoring electrocardiographic (ECG) findings after intravenous HAL, During a a-month period, 47 patients received intravenous injections to control psychotic disruptive behavior. According to clinical practice, patients were divided as follows. The FZ-alone group was treated with intravenous flunitrazepam (FZ), and the FZ-plus-HAL group received intravenous FZ followed by intravenous HAL, Although the difference in the mean QTc immediately after intravenous FZ between the twogroups was not significant, the mean QTc after 8 hours in the FZ-plus-HAL group was longer than that in the FZ-alone group (p < 0.001), Four patientsin the FZ-plus-HAL group had a QTc of more than 500 msec after 8 hours. The change in QTc during 8 hours significantly differed between the two groups (t = 2.64,p > 0.05), Furthermore, the change in QTc was moderately correlated with the dose of intravenous HAL, as evidenced by a coefficient of correlation of 0.48 (p < 0.001), However, ventricular tachyarrhythmia was not detected among 307 patients within a 1-year period, although the ECG was continuously monitored for at least 8 hours after intravenous HAL, The modestnature of QTc prolongation and the apparent absence of ventricular tachyarrhythmia under continuous ECG monitoring indicate that QTc prolongation associated with intravenous HAL is not necessarily dangerous. However, in an emergency situation, clinicians cannot exclude patients predisposed to torsade de pointes, such as those with inherited ion channel disorders. Therefore, clinicians should be aware of the association between intravenous HAL and QT prolongation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 18:41:08