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Titolo:
Threshold of fragmentation for ultrasonic contrast agents
Autore:
Chomas, JE; Dayton, P; May, D; Ferrara, K;
Indirizzi:
Univ Calif Davis, Div Biomed Engn, Davis, CA 95616 USA Univ Calif Davis Davis CA USA 95616 Div Biomed Engn, Davis, CA 95616 USA
Titolo Testata:
JOURNAL OF BIOMEDICAL OPTICS
fascicolo: 2, volume: 6, anno: 2001,
pagine: 141 - 150
SICI:
1083-3668(200104)6:2<141:TOFFUC>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
DIAGNOSTIC ULTRASOUND; CAVITATION; DESTRUCTION; PULSE;
Keywords:
ultrasound; contrast agents; blood flow; optical observation; fragmentation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Engineering, Computing & Technology
Citazioni:
14
Recensione:
Indirizzi per estratti:
Indirizzo: Chomas, JE Univ Calif Davis, Div Biomed Engn, 1228 Bainer Hall, Davis, CA 95616 USA Univ Calif Davis 1228 Bainer Hall Davis CA USA 95616 95616 USA
Citazione:
J.E. Chomas et al., "Threshold of fragmentation for ultrasonic contrast agents", J BIOMED OP, 6(2), 2001, pp. 141-150

Abstract

Ultrasound contrast agents are small microbubbles that can be readily destroyed with sufficient acoustic pressure, typically, at a frequency in the low megaHertz range. Microvascular flow rate may be estimated by destroying the contrast agent in a vascular bed, and estimating the rate of flow of contrast agents back into the vascular bed. Characterization of contrast agent destruction provides important information for the design of this technique. In this paper, high-speed optical observation of an ultrasound contrastagent during acoustic insonation is performed. The resting diameter is shown to be a significant parameter in the prediction of microbubble destruction, with smaller diameters typically correlated with destruction. Pressure,center frequency, and transmission phase are each shown to have a significant effect on the fragmentation threshold. A linear prediction for the fragmentation threshold as a function of pressure, when normalized by the resting diameter, has a rate of change of 300 kPa/mum for the range of pressuresfrom 310 to 1200 kPa, and a two-cycle excitation pulse with a center frequency of 2.25 MHz. A linear prediction for the fragmentation threshold as a function of frequency, when normalized by the resting diameter, has a rate of change of -1.2 MHz/mum for a transmission pressure of 800 kPa, and a two-cycle excitation pulse with a range of frequencies from 1 to 5 MHz. (C) 2001 Society oi Photo-Optical Instrumentation Engineers.

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Documento generato il 20/09/20 alle ore 01:07:13