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Titolo:
Idiopathic environmental intolerance: Increased prevalence of panic disorder-associated cholecystokinin B receptor allele 7
Autore:
Binkley, K; King, N; Poonai, N; Seeman, P; Ulpian, C; Kennedy, J;
Indirizzi:
Univ Toronto, Gage Occupat & Environm Hlth Unit, Toronto, ON, Canada Univ Toronto Toronto ON Canada & Environm Hlth Unit, Toronto, ON, Canada Univ Toronto, Div Clin Immunol & Allergy, Dept Med, St Michaels Hosp, Toronto, ON, Canada Univ Toronto Toronto ON Canada ed, St Michaels Hosp, Toronto, ON, Canada Univ Toronto, Neurogenet Sect, Clarke Div, Ctr Addict & Mental Hlth, Toronto, ON, Canada Univ Toronto Toronto ON Canada Addict & Mental Hlth, Toronto, ON, Canada Univ Toronto, Dept Pharmacol, Toronto, ON, Canada Univ Toronto Toronto ONCanada onto, Dept Pharmacol, Toronto, ON, Canada Univ Toronto, Dept Psychiat, Toronto, ON, Canada Univ Toronto Toronto ON Canada ronto, Dept Psychiat, Toronto, ON, Canada
Titolo Testata:
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
fascicolo: 5, volume: 107, anno: 2001,
pagine: 887 - 890
SICI:
0091-6749(200105)107:5<887:IEIIPO>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
MULTIPLE CHEMICAL-SENSITIVITY; NOVELTY SEEKING; ILLNESS; POLYMORPHISMS; PSEUDOALLERGY; CHALLENGES; PATIENT; ALLERGY; GENES; DRD4;
Keywords:
idiopathic environmental intolerance; panic disorder; cholecystokinin; cholecystokinin B receptor; dopamine D4; dopamine D4 receptor gene; genetic association study;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Binkley, K 201-30 St Clair Ave W, Toronto, ON M4V 3A1, Canada 201-30 St Clair Ave W Toronto ON Canada M4V 3A1 4V 3A1, Canada
Citazione:
K. Binkley et al., "Idiopathic environmental intolerance: Increased prevalence of panic disorder-associated cholecystokinin B receptor allele 7", J ALLERG CL, 107(5), 2001, pp. 887-890

Abstract

Background: A growing body of evidence suggests that idiopathic environmental intolerance (IEI) is a psychophysiologic disorder with prominent features of anxiety/panic and somatization, although proponents of a toxicogenic explanation claim, despite a lack of convincing evidence, that symptoms arise from exposure to otherwise nonnoxious environmental agents. Patient behaviour is characterized by strenuous avoidance of perceived triggers to the point of severe impairment of normal social and vocational functioning. IEIproponents claim that previous studies showing a high prevalence of psychopathology in patients with IEI and studies showing panic responses to knownpanicogenic challenges merely reflect the anxiety-producing result of living with IEI,Objective: We explored whether IEI and panic disorder, personality traits,or both shared an underlying neurogenetic basis that would predate the anxiety of IEI symptomatology. The DNA of patients with IEI was examined for the presence of known panic disorder-associated cholecystokinin B (CCK-B) receptor alleles and for personality trait-associated dopamine D4 receptor polymorphisms. Methods: Eleven patients with typical IEI symptoms were recruited and wereindividually matched to normal control subjects from an existing bank for age, sex, and ethnic background. Genomic DNA was extracted from peripheral blood samples. CCK-B and dopamine D4 receptor polymorphisms were examined by using standard PCR-based techniques,Results: There was a significantly higher prevalence of the panic disorder-associated CCK-B receptor allele 7 in subjects with IEI (9/22 [40.9%) compared with control subjects (2/22 [9,1%, P = ,037), There was no difference in personality trait-associated polymorphisms of the gene encoding dopamineD4 receptor between patients and control subjects. Conclusions: These findings provide preliminary evidence that IEI and panic disorder share a common neurogenetic basis, which would predate the anxiety-producing effects of IEI symptoms, Further studies with larger samples are warranted, but these results support previous studies that suggest that panic disorder may account for much of the symptomatology in at Least some cases of IEI and provide a basis for rational treatment strategies.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 14:28:37