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Titolo:
Healthy subjects express differences in clinical responses to inhaled lipopolysaccharide that are related with inflammation and with atopy
Autore:
Michel, O; Dentener, M; Corazza, F; Buurman, W; Rylander, R;
Indirizzi:
Hop Univ St Pierre, Clin Allergol, B-1000 Brussels, Belgium Hop Univ St Pierre Brussels Belgium B-1000 gol, B-1000 Brussels, Belgium Hop Univ St Pierre, Clin Resp Dis, B-1000 Brussels, Belgium Hop Univ St Pierre Brussels Belgium B-1000 Dis, B-1000 Brussels, Belgium Free Univ Brussels, CHU Brugmann, Clin Haematol, Brussels, Belgium Free Univ Brussels Brussels Belgium n, Clin Haematol, Brussels, Belgium Maastricht Univ, Dept Pulmonol, Maastricht, Netherlands Maastricht Univ Maastricht Netherlands ulmonol, Maastricht, Netherlands Maastricht Univ, Dept Surg, Maastricht, Netherlands Maastricht Univ Maastricht Netherlands pt Surg, Maastricht, Netherlands Univ Gothenburg, Dept Environm Med, Gothenburg, Sweden Univ Gothenburg Gothenburg Sweden Dept Environm Med, Gothenburg, Sweden
Titolo Testata:
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
fascicolo: 5, volume: 107, anno: 2001,
pagine: 797 - 804
SICI:
0091-6749(200105)107:5<797:HSEDIC>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
PERMEABILITY-INCREASING PROTEIN; ENDOTOXIN EXPOSURE; INDUCED SPUTUM; BRONCHIAL RESPONSIVENESS; BINDING PROTEIN; DENDRITIC CELLS; COTTON DUST; ASTHMA; POLYMORPHISM; DETERMINANT;
Keywords:
endotoxin; fever; airway responsiveness; inflammation; atopy;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
48
Recensione:
Indirizzi per estratti:
Indirizzo: Michel, O Free Univ Brussels, CHU St Pierre, Clin Allergol & Resp Dis, RueHaute 290, B-1000 Brussels, Belgium Free Univ Brussels Rue Haute 290 Brussels Belgium B-1000 elgium
Citazione:
O. Michel et al., "Healthy subjects express differences in clinical responses to inhaled lipopolysaccharide that are related with inflammation and with atopy", J ALLERG CL, 107(5), 2001, pp. 797-804

Abstract

Background: Endotoxin and its purified derivative LPS are important contaminants of both domestic and occupational environments that have been related to airway diseases. A body of data suggests that there is considerable interindividual variability in LPS sensitivity. Objective: The aim of the study was to relate the individual clinical responses to inhaled LPS with the inflammatory process and the atopic status. Methods: Fifteen healthy subjects were challenged each week by inhalation,vith saline solution or LPS (0.5, 5, or 50 mug). The systemic response was defined by the increase in body temperature, blood neutrophilia, acute-phase proteins (C-reactive protein and LPS-binding protein [LBP]), and E-selectin. The LPS-induced airway response was defined as the increase in airway responsiveness and related to the cell count and concentration of TNF-alpha,myeloperoxidase, and eosinophil cationic protein in induced sputum. The atopic status was defined as an increase in IgE or a positive skin prick testresult. Results: Subjects (n = 7) with a significant increase in body temperature had a larger increase in the systemic inflammatory response (blood neutrophilia; P < .01) and in blood concentrations of C-reactive protein (P < .02) and LBP (P < .01). Subjects with a significant increase in airway responsiveness (n = 8) had an increase in the sputum concentration of eosinophil cationic protein (P < .01), The amplitude of the systemic response (increase in body temperature [P < .001], blood neutrophilia [P < .02], and rise in LBP [P < .05] and decrease in FEV, [P < .01]) were inversely associated with the atopic status, suggesting a link between atopy and LPS responsiveness. Conclusions: The clinical response to LPS occurs systemically or locally and is associated with inflammation. The atopic status was inversely relatedto the systemic inflammation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/02/20 alle ore 21:04:25