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Titolo:
High prevalence of genotypic and phenotypic HIV-1 drug-resistant strains among patients receiving antiretroviral therapy in Abidjan, Cote d'Ivoire
Autore:
Adje, C; Cheingsong, R; Roels, TH; Maurice, C; Djomand, G; Verbiest, W; Hertogs, K; Larder, B; Monga, B; Peeters, M; Eholie, S; Bissagene, E; Coulibaly, M; Respess, R; Wiktor, SZ; Chorba, T; Nkengasong, JN;
Indirizzi:
Projet RETRO CI, Virol Lab, Abidjan, Cote Ivoire Projet RETRO CI AbidjanCote Ivoire CI, Virol Lab, Abidjan, Cote Ivoire Ctr Dis Control & Prevent, Div AIDS STD, TB Lab Res, Natl Ctr Infect Dis, Atlanta, GA USA Ctr Dis Control & Prevent Atlanta GA USA Ctr Infect Dis, Atlanta, GA USA Ctr Dis Control & Prevent, Div HIV AIDS Prevent, Natl Ctr STD HIV & TB Prevent, Atlanta, GA USA Ctr Dis Control & Prevent Atlanta GA USA V & TB Prevent, Atlanta, GA USA VIRCO NV, Mechelen, Belgium VIRCO NV Mechelen BelgiumVIRCO NV, Mechelen, Belgium VIRCO, Cambridge, England VIRCO Cambridge EnglandVIRCO, Cambridge, England IRD, Montpellier, France IRD Montpellier FranceIRD, Montpellier, France Univ Hosp, Infect Dis Clin, Abidjan, Cote Ivoire Univ Hosp Abidjan Cote Ivoire sp, Infect Dis Clin, Abidjan, Cote Ivoire UNAIDS, Abidjan, Cote Ivoire UNAIDS Abidjan Cote IvoireUNAIDS, Abidjan, Cote Ivoire
Titolo Testata:
JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES
fascicolo: 5, volume: 26, anno: 2001,
pagine: 501 - 506
SICI:
1525-4135(20010415)26:5<501:HPOGAP>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
IMMUNODEFICIENCY-VIRUS INFECTION; PROTEASE INHIBITOR THERAPY; SUSCEPTIBILITY; RNA;
Keywords:
Africa-antiretroviral therapy; epidemiology; HIV drug resistance; mutations; HIV subtypes;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
17
Recensione:
Indirizzi per estratti:
Indirizzo: Nkengasong, JN Projet RETRO CI, Virol Lab, 01 BP 1712, Abidjan, Cote Ivoire Projet RETRO CI 01 BP 1712 Abidjan Cote Ivoire ote Ivoire
Citazione:
C. Adje et al., "High prevalence of genotypic and phenotypic HIV-1 drug-resistant strains among patients receiving antiretroviral therapy in Abidjan, Cote d'Ivoire", J ACQ IMM D, 26(5), 2001, pp. 501-506

Abstract

To describe prevalence of antiretroviral (ARV) drug-resistant HIV-1 strains among patients with a history of earlier treatment with ARV drugs in Abidjan, Cote d'Ivoire. we determined mutations that confer HIV-1 ARV drug resistance by sequencing the viral reverse-transcriptase and protease genes derived from plasma viral RNA of 68 individuals consecutively enrolled in the Joint United Nations Program on AIDS Drug Access Initiative (UNAIDS-DAI) with a history of earlier ARV drug treatment in Abidjan between August 1998 and April 1999. Phenotypic ARV drug resistance was assessed using a recombinant virus assay. Primary mutations associated with ARV drug resistance to at least one of the reverse-transcriptase inhibitors or protease inhibitors were detected in 39 (57.4%) of the 68 patients. The prevalence of mutationsassociated with resistance to ARV drugs was: 29 (42.6%) to zidovudine, 10 (14.7%) to lamivudine, one (1.5%) to didanosine, one K103N mutation (associated with resistance to delavirdine, nevirapine, and efavirenz), one Y181C mutation (associated with resistance to delavirdine and nevirapine). two toboth indinavir (M46I/L and V82A) and saquinavir (G48V and L90M). and one each to ritonavir (V82A) and nelfinavir (D30N). Phenotypic resistance to at least one nucleoside reverse transcriptase inhibitor (RTI) was seen in 25 (39.7%) patients, to nonnucleoside RTIs in 5 (8%) patients. and to protease inhibitors in 4 (6%) patients. The high prevalence we observed in this study may limit in future the effectiveness of ARV programs in the Cote d'Ivoire.

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Documento generato il 05/04/20 alle ore 03:45:27