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Titolo:
Mortality in a cohort of HIV-infected adults started on a protease inhibitor-containing therapy - Standardization to the general population
Autore:
Lewden, C; Raffi, F; Chene, G; Sobel, A; Leport, C;
Indirizzi:
Fac Xavier Bichat, Lab Pathol Infect, F-75870 Paris 18, France Fac Xavier Bichat Paris France 18 athol Infect, F-75870 Paris 18, France Hop Henri Mondor, Serv Immunol Clin, F-94010 Creteil, France Hop Henri Mondor Creteil France F-94010 ol Clin, F-94010 Creteil, France Unite Malad Infect & Trop, Nantes, France Unite Malad Infect & Trop Nantes France d Infect & Trop, Nantes, France INSERM, U330, Bordeaux, France INSERM Bordeaux FranceINSERM, U330, Bordeaux, France
Titolo Testata:
JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES
fascicolo: 5, volume: 26, anno: 2001,
pagine: 480 - 482
SICI:
1525-4135(20010415)26:5<480:MIACOH>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
SURVIVAL;
Keywords:
HIV-1 infection; HAART; protease inhibitors; mortality; standardization;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
6
Recensione:
Indirizzi per estratti:
Indirizzo: Leport, C Fac Xavier Bichat, Lab Pathol Infect, F-75870 Paris 18, France Fac Xavier Bichat Paris France 18 ct, F-75870 Paris 18, France
Citazione:
C. Lewden et al., "Mortality in a cohort of HIV-infected adults started on a protease inhibitor-containing therapy - Standardization to the general population", J ACQ IMM D, 26(5), 2001, pp. 480-482

Abstract

Death rates in the APROCO cohort of 1,157 HIV-1 infected adults starting for the first time a protease inhibitor-containing therapy were standardizedto the 1996 French general population mortality rates stratified by age and gender. Median follow up was 23 months and mortality rate was 2.2% person-years (95% confidence interval [CI] = 1.6-2.9). Overall mortality was 7.8 times higher than in the general population (95% CI = 5.7-10.4), 4.7 in menand 19.5 in women. Among the 144 patients considered complete responders, the death rate was 1.2% person-years (95% CI 0.2-3.5) and mortality remained 5.1 times higher (95% CI = 1.0-14.9) than in the general population. Failure of treatment, long-term adverse effects, or less favorable socio-demographic status could explain these trends.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 16:09:09