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Titolo:
Relation between HIV-1 and hepatitis C viral load in patients with hemophilia
Autore:
Daar, ES; Lynn, H; Donfield, S; Gomperts, E; Hilgartner, MW; Hoots, WK; Chernoff, D; Arkin, S; Wong, WY; Winkler, CA;
Indirizzi:
Univ Calif Los Angeles, Sch Med, Los Angeles, CA USA Univ Calif Los Angeles Los Angeles CA USA , Sch Med, Los Angeles, CA USA Cedars Sinai Burns & Allen Res Inst, Dept Med, Div Infect Dis, Los Angeles, CA USA Cedars Sinai Burns & Allen Res Inst Los Angeles CA USA s Angeles, CA USA Rho Inc, Chapel Hill, NC USA Rho Inc Chapel Hill NC USARho Inc, Chapel Hill, NC USA Childrens Hosp Los Angeles, Los Angeles, CA 90027 USA Childrens Hosp Los Angeles Los Angeles CA USA 90027 Angeles, CA 90027 USA New York Hosp, Cornell Med Ctr, Div Pediat Hematol & Oncol, New York, NY USA New York Hosp New York NY USA v Pediat Hematol & Oncol, New York, NY USA Univ Texas, Sch Med, Dept Pediat, Houston, TX USA Univ Texas Houston TX USA v Texas, Sch Med, Dept Pediat, Houston, TX USA Univ Texas, Sch Med, Dept Internal Med, Houston, TX USA Univ Texas Houston TX USA s, Sch Med, Dept Internal Med, Houston, TX USA Chiron Corp, Emeryville, CA 94608 USA Chiron Corp Emeryville CA USA 94608Chiron Corp, Emeryville, CA 94608 USA Schneider Childrens Hosp, Div Pediat Hematol Oncol & Stem Cell Transplantat, New Hyde Park, NY USA Schneider Childrens Hosp New Hyde Park NY USA tat, New Hyde Park, NY USA NCI, SAIC, Frederick Canc Res & Dev Ctr, Frederick, MD 21701 USA NCI Frederick MD USA 21701 ck Canc Res & Dev Ctr, Frederick, MD 21701 USA
Titolo Testata:
JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES
fascicolo: 5, volume: 26, anno: 2001,
pagine: 466 - 472
SICI:
1525-4135(20010415)26:5<466:RBHAHC>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN-IMMUNODEFICIENCY-VIRUS; T-CELL RESPONSES; DISEASE PROGRESSION; DRUG-USERS; LIVER-DISEASE; IMMUNE-RESPONSES; RNA LEVELS; HCV RNA; INFECTION; VIREMIA;
Keywords:
HIV-1 viral load; HCV viral load; HIV-1 pathogenesis; hepatitis C virus; human immunodeficiency virus; hepatitis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
46
Recensione:
Indirizzi per estratti:
Indirizzo: Daar, ES Cedars Sinai Med Ctr, Div Infect Dis, 1130E,8700 Beverly Blvd, Los Angeles, CA 90048 USA Cedars Sinai Med Ctr 1130E,8700 Beverly Blvd Los Angeles CA USA 90048
Citazione:
E.S. Daar et al., "Relation between HIV-1 and hepatitis C viral load in patients with hemophilia", J ACQ IMM D, 26(5), 2001, pp. 466-472

Abstract

Coinfection with hepatitis C virus (HCV) and HIV-1 is common in patients with hemophilia and in intravenous drug users. Little, however, is known about the relation between HIV-1 and HCV coinfection and the effects on HCV clearance and pathogenesis. We examined data from 207 HIV-1-infected and 126 HIV-1-uninfected patients with hemophilia enrolled in the multicenter Hemophilia Growth and Development Study. Participants were observed during prospective follow-up for approximately 7 years with annual measurements of alanine aminotransferase (ALT), CD4(+) cells, and HCV and HIV-1 RNA levels. Clearance of HCV was more likely to occur in those uninfected with HIV-1 (14.3versus 2.5%; odds ratio [OR] 4.79: 95% confidence interval [CI], 1.63-14.08. p = .005) and was more common with decreasing age (OR, 1.23; 95% CI, 1.04-1.47; p = .017). HCV RNA levels were higher throughout the 7 years of follow-up in those HIV-1-infected (p < .001). In the HIV-1-infected participants, baseline CD4(+) cells were inversely related to HCV RNA with every 100-cell increase associated with a 0.19 log(10) copy/ml decrease in HCV RNA (p= .002), and HIV-1 and HCV RNA levels were directly related (p = .008). Increasing HCV RNA levels were also associated with significantly higher ALT levels regardless of HIV-1 infection status. These results demonstrate thatHIV-1/HCV coinfection is associated with a reduced likelihood of HCV clearance and that higher levels of HCV RNA are associated with increased hepatic inflammation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 00:14:23