Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Altered fat distribution in HIV-positive men on nucleoside analog reverse transcriptase inhibitor therapy
Autore:
Mulligan, K; Tai, VW; Algren, H; Abrams, DI; Leiser, RJ; Lo, JC; Schambelan, M;
Indirizzi:
San Francisco Gen Hosp, Div Endocrinol, San Francisco, CA 94110 USA San Francisco Gen Hosp San Francisco CA USA 94110 Francisco, CA 94110 USA Univ Calif San Francisco, Dept Med, San Francisco, CA USA Univ Calif San Francisco San Francisco CA USA Med, San Francisco, CA USA San Francisco Gen Hosp, Community Consortium & Posit Hlth Program, San Francisco, CA 94110 USA San Francisco Gen Hosp San Francisco CA USA 94110 Francisco, CA 94110 USA
Titolo Testata:
JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES
fascicolo: 5, volume: 26, anno: 2001,
pagine: 443 - 448
SICI:
1525-4135(20010415)26:5<443:AFDIHM>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN-IMMUNODEFICIENCY-VIRUS; ANTIRETROVIRAL-THERAPY; INSULIN-RESISTANCE; BODY-COMPOSITION; ABDOMINAL-FAT; LIPODYSTROPHY; INFECTION; HYPERLIPIDEMIA; PATHOGENESIS; WOMEN;
Keywords:
fat distribution; DEXA; body composition; wasting syndrome; lipodystrophy; nucleoside analog reverse transcriptase inhibitors; protease inhibitors;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Mulligan, K San Francisco Gen Hosp, Div Endocrinol, Bldg 30,Room 3501K,1001 Potrero Ave, San Francisco, CA 94110 USA San Francisco Gen Hosp Bldg 30,Room 3501K,1001 Potrero Ave San Francisco CA USA 94110
Citazione:
K. Mulligan et al., "Altered fat distribution in HIV-positive men on nucleoside analog reverse transcriptase inhibitor therapy", J ACQ IMM D, 26(5), 2001, pp. 443-448

Abstract

To determine whether HIV infection, the wasting syndrome, or nucleoside analog reverse transcriptase inhibitor (NRTI) or protease inhibitor (PI) therapy uniquely affect fat distribution in men, we performed manual regional analysis of total, appendicular, trunk, and central abdominal fat measured by dual-energy X-ray absorptiometry (DEXA). Five groups of study subjects were identified for this cross-sectional analysis: HIV-negative controls (HIV-: N = 44) and four groups of HIV-positive subjects: antiretroviral (ARV)-naive or with limited prior use of NRTIs (ARV-; N = 23): on NRTIs for greater than or equal to6 months but PI-naive (NRTI; N = 30), on an NRTI/PI regimen for greater than or equal to6 months but with no complaints of abnormal fat distribution (NRTI/PI; N = 26): and those on NRTIs but PI-naive with the wasting syndrome (NRTI/WS, N = 40). Total, appendicular, trunk, and central abdominal fat was significantly lower in NRTI/WS. The ratio of trunk fatto appendicular fat was virtually identical in HIV- and ARV-. This ratio was significantly higher in the NRTI, NRTI/PI, and NRTI/WS groups, and values in these three groups were similar. These cross-sectional data suggest that HIV-infected men receiving NRTIs have an altered pattern of fat distribution, compared with HIV-negative men and HIV-positive men who are not receiving antiretroviral therapy. This effect was independent of the concomitantuse of a PI or a diagnosis of the wasting syndrome. We saw no evidence of a unique effect of HIV infection per se on regional fat distribution. Although the fat ratio is increasingly employed, its physiologic significance isunclear. Our results, which have been obtained retrospectively, are intended to provide the impetus for prospective. controlled studies of the interactions among drug and host factors in the development of fat distribution abnormalities.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 16:04:11