Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Effect of drug efficacy and the eclipse phase of the viral life cycle on estimates of HIV viral dynamic parameters
Autore:
Nelson, PW; Mittler, JE; Perelson, AS;
Indirizzi:
Univ Calif Los Alamos Natl Lab, Theoret Biol & Biophys Grp, Los Alamos, NM87545 USA Univ Calif Los Alamos Natl Lab Los Alamos NM USA 87545 lamos, NM87545 USA Univ Michigan, Dept Math, Ann Arbor, MI 48109 USA Univ Michigan Ann ArborMI USA 48109 , Dept Math, Ann Arbor, MI 48109 USA
Titolo Testata:
JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES
fascicolo: 5, volume: 26, anno: 2001,
pagine: 405 - 412
SICI:
1525-4135(20010415)26:5<405:EODEAT>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN-IMMUNODEFICIENCY-VIRUS; ACTIVE ANTIRETROVIRAL THERAPY; FOLLICULAR DENDRITIC CELLS; MATHEMATICAL-ANALYSIS; INTRACELLULAR DELAY; IN-VIVO; TYPE-1 INFECTION; CLEARANCE RATE; DECAY-RATES; TRANSCRIPTION;
Keywords:
HIV-HIV pathogenesis; mathematical modeling; viral dynamics;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Perelson, AS Univ Calif Los Alamos Natl Lab, Theoret Biol & Biophys Grp, MS-K710,T-10, Los Alamos, NM 87545 USA Univ Calif Los Alamos Natl Lab MS-K710,T-10 Los Alamos NM USA 87545
Citazione:
P.W. Nelson et al., "Effect of drug efficacy and the eclipse phase of the viral life cycle on estimates of HIV viral dynamic parameters", J ACQ IMM D, 26(5), 2001, pp. 405-412

Abstract

Fits of mathematic models to the decline in HIV-1 RNA after antiretroviraltherapies have yielded estimates for the life span of productively infected cells of 1 to 2 days. In a previous report, we described the mathematic properties of an extended model that accounts for imperfect viral suppression and the eclipse phase of the viral life cycle (the intracellular delay between initial infection and release of progeny virions). In this article, we fit this extended model to detailed data on the decline of plasma HIV-1 RNA after treatment with the protease inhibitor ritonavir. Because the therapy in this study was most likely not completely suppressive, we allowed thedrug efficacy parameter to vary from 70% to 100%. Estimates for the clearance rate of free virus, c, increased with the addition of the intracellulardelay (as reported previously) but were not appreciably affected by changes in the drug efficacy parameter. By contrast, the estimated death rate of virus-producing cells, delta, increased from an average of 0.49 day(-1) to 0.90 day(-1) (an increase of 84%) because the drug efficacy parameter was reduced from 100% to 70%. Neglecting the intracellular delay, the comparableincrease in delta was only about 55%. The inferred increases in delta doubled when the model was extended to account for possible increases in targetcell densities after treatment initiation. This work suggests that estimates for delta may be greater than previously reported and that the half-lifeof a cell in vivo that is producing virus, on average, may be 1 day.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 01:42:32