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Titolo:
Transdermal administration of salmon calcitonin by pulse depolarization-iontophoresis in rats
Autore:
Nakamura, K; Katagai, K; Mori, K; Higo, N; Sato, S; Yamamoto, K;
Indirizzi:
Hisamitsu Pharmaceut Co Inc, R&D Planning Dept, Shinagawa Ku, Tokyo 1410031, Japan Hisamitsu Pharmaceut Co Inc Tokyo Japan 1410031 Ku, Tokyo 1410031, Japan Hisamitsu Pharmaceut Co Inc, TTS Res Labs, Tsukuba, Ibaraki 3050856, JapanHisamitsu Pharmaceut Co Inc Tsukuba Ibaraki Japan 3050856 3050856, Japan Chiba Univ, Fac Pharmaceut Sci, Inage Ku, Chiba 2638522, Japan Chiba UnivChiba Japan 2638522 aceut Sci, Inage Ku, Chiba 2638522, Japan
Titolo Testata:
INTERNATIONAL JOURNAL OF PHARMACEUTICS
fascicolo: 1-2, volume: 218, anno: 2001,
pagine: 93 - 102
SICI:
0378-5173(20010507)218:1-2<93:TAOSCB>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
EXCISED HUMAN-SKIN; STRATUM-CORNEUM; DELIVERY; DRUGS;
Keywords:
bioavailability; pulse depolarization; iontophoresis delivery; salmon calcitonin; transdermal administration;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
18
Recensione:
Indirizzi per estratti:
Indirizzo: Nakamura, K Hisamitsu Pharmaceut Co Inc, R&D Planning Dept, Shinagawa Ku, Nishigotanda6-25-8, Tokyo 1410031, Japan Hisamitsu Pharmaceut Co Inc Nishigotanda 6-25-8 Tokyo Japan 1410031
Citazione:
K. Nakamura et al., "Transdermal administration of salmon calcitonin by pulse depolarization-iontophoresis in rats", INT J PHARM, 218(1-2), 2001, pp. 93-102

Abstract

Using the pulse depolarization-iontophoresis (PDP-IP) system, salmon calcitonin (sCT), a drug for the treatment of osteoporosis, was transdermaly administered in rats. While absorption of sCT was not observed after passive transdermal administration, the set um sCT concentration was confirmed at adose of 0.2-4 mug when the PDP-IP system was employed. The results indicatedthat PDP-IP could enhance transdermal absorption of peptide drugs. Also noted was the increased amount of absorption of sCT along with an increase inthe dose. We investigated the influence of electrical parameters (current,frequency) in PDP-IP on the transdermal absorption of sCT. An optimal current for drug absorption was found within the range of transported current (0.1-1.0 mA) employed for PDP-IP. In comparison with the results obtained at0.1 mA, the drug absorption increased, along with an increase in transported current, when the current was set at 0.5 mA. while the drug absorption decreased at 1.0 mA in comparison. The decrease in drug absorption was assumed to be attributable to the structural destruction of skin by application of excessive current. There was no change in skin resistance attributable to the frequency, nor was there any influence of the frequency on the amountof drug absorption. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 16/07/20 alle ore 06:13:01