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Titolo:
Effect of ethanol and isopropyl myristate on the availability of topical terbinafine in human stratum corneum, in vivo
Autore:
Alberti, I; Kalia, YN; Naik, A; Bonny, JD; Guy, RH;
Indirizzi:
Ctr Interuniv Rech & Enseignement Pharmapeptides, F-74166 Archamps, FranceCtr Interuniv Rech & Enseignement Pharmapeptides Archamps France F-74166 Univ Geneva, Pharm Sect, Pharm Galen Lab, CH-1211 Geneva 4, Switzerland Univ Geneva Geneva Switzerland 4 alen Lab, CH-1211 Geneva 4, Switzerland Novartis Pharma AG, CH-4002 Basel, Switzerland Novartis Pharma AG Basel Switzerland CH-4002 CH-4002 Basel, Switzerland
Titolo Testata:
INTERNATIONAL JOURNAL OF PHARMACEUTICS
fascicolo: 1-2, volume: 219, anno: 2001,
pagine: 11 - 19
SICI:
0378-5173(20010521)219:1-2<11:EOEAIM>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
REFLECTANCE INFRARED-SPECTROSCOPY; TRADITIONAL DIFFUSION CELLS; ATR-FTIR SPECTROSCOPY; IN-VIVO; SYNTHETIC MEMBRANES; PERMEABILITY DATA; DRUG CONTENT; SKIN; BIOAVAILABILITY; FEASIBILITY;
Keywords:
antimycotics; topical vehicles; topical administration; topical bioavailability; Fourier transform infrared spectroscopy; tape stripping;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
17
Recensione:
Indirizzi per estratti:
Indirizzo: Guy, RH Ctr Interuniv Rech & Enseignement Pharmapeptides, Campus Univ,ParcAffaires Int, F-74166 Archamps, France Ctr Interuniv Rech & Enseignement Pharmapeptides Campus Univ,Parc Affaires Int Archamps France F-74166
Citazione:
I. Alberti et al., "Effect of ethanol and isopropyl myristate on the availability of topical terbinafine in human stratum corneum, in vivo", INT J PHARM, 219(1-2), 2001, pp. 11-19

Abstract

Purpose: The objective of this study was to determine the availability of the topical drug terbinafine (TBF) in human stratum corneum (SC) in vivo following its administration in formulations containing isopropyl myristate and ethanol. Methods: The ventral forearms of human volunteers were treated for 4 h with TBF, at a concentration equal to 1/4 saturation, in isopropyl myristate (IPM), in ethanol (EtOH) and in 50:50 v/v IPM/EtOH. At the end ofthe application period, the treated sites were carefully cleaned of excessvehicle and the SC was progressively removed by sequential tape stripping. TBF was quantified in the SC by: (a) extraction of the tape strips and subsequent HPLC analysis; and (b) attenuated total reflectance infrared spectroscopy (ATR-FTIR) of each sequentially exposed SC surface during the tape stripping procedure. Results: The concentration profile of TBF in the SC (i.e. drug concentration as a function of depth in the membrane) was fitted tothe appropriate solution of Fick's second law of diffusion, allowing thereby the drug's SC/vehicle partition coefficient (K) and characteristic diffusion parameter (D/L-2, where D is the diffusivity of TBF in the SC of thickness L) to be deduced. Conclusions: While D/L-2 for TBF derived from the three vehicles remained essentially constant, the drug's partitioning into the SC was significantly higher from formulations containing ethanol. Both the semi-quantitative infrared data and the more rigorous HPLC results supported these deductions. (C) 2001 Elsevier Science B.V. All rights reserved.

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Documento generato il 04/06/20 alle ore 01:40:06