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Titolo:
Genetic and epigenetic events in human hepatocarcinogenesis (Review)
Autore:
Kondoh, N; Wakatsuki, T; Hada, A; Shuda, M; Tanaka, K; Arai, M; Yamamoto, M;
Indirizzi:
Natl Def Med Coll, Dept Biochem 2, Tokorozawa, Saitama 3598513, Japan NatlDef Med Coll Tokorozawa Saitama Japan 3598513 Saitama 3598513, Japan Tokyo Med & Dent Univ, Dept Microbiol & Mol Virol, Bunkyo Ku, Tokyo 1138519, Japan Tokyo Med & Dent Univ Tokyo Japan 1138519 unkyo Ku, Tokyo 1138519, Japan
Titolo Testata:
INTERNATIONAL JOURNAL OF ONCOLOGY
fascicolo: 6, volume: 18, anno: 2001,
pagine: 1271 - 1278
SICI:
1019-6439(200106)18:6<1271:GAEEIH>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
HEPATITIS-C VIRUS; HUMAN HEPATOCELLULAR-CARCINOMA; COMPARATIVE GENOMIC HYBRIDIZATION; ACTIVATED PROTEIN-KINASES; BETA-CATENIN MUTATIONS; RAT EMBRYO FIBROBLASTS; GROWTH-FACTOR RECEPTOR; FREQUENT ALLELIC LOSS; NECROSIS-FACTOR-ALPHA; B-VIRUS;
Keywords:
hepatocellular carcinoma; morecular medicine; hepatitis viruses;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
137
Recensione:
Indirizzi per estratti:
Indirizzo: Yamamoto, M Natl Def Med Coll, Dept Biochem 2, Namiki 3-2, Tokorozawa, Saitama 3598513, Japan Natl Def Med Coll Namiki 3-2 Tokorozawa Saitama Japan 3598513
Citazione:
N. Kondoh et al., "Genetic and epigenetic events in human hepatocarcinogenesis (Review)", INT J ONCOL, 18(6), 2001, pp. 1271-1278

Abstract

Hepatocellular carcinoma (HCC) is the most frequently occurring liver carcinoma world-wide. Clinical and molecular medical analyses have produced a considerable amount of information about liver carcinogenesis. Loss of heterozygosity (LOH) analyses have revealed several chromosomal loci harboring potential tumor suppressors. These data support the idea that deletion or inactivation of tumor suppressors including RE, p53, BRCA2, E-cadherin and other candidate genes seem to be common events in I-ICC development. Factors associated with cell cycle regulation via the Wnt- and MAPK/ERK signaling pathways are frequently deregulated in hepatocarcinogenesis. Aberrant activation of telomerase also occurs in precancerous as well as cancerous lesionsin HCC patients. To characterize the wide variety of; genetic events that occur in HCC, mRNA expression has been compared in HCC and non-cancerous liver tissues, and several differentially expressed genes have been identified. Hepatitis B and C viruses are the main risk factors for HCC, and indeed some accessory functions of viral products seem to contribute to tumor development; however, whether they have a direct carcinogenic effect has not yet been established.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/08/20 alle ore 12:53:02