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Titolo:
Cell proliferation, cell death, E-cadherin, metalloproteinase expression and angiogenesis in gastric cancer precursors and early cancer of the intestinal type
Autore:
Spina, D; Vindigni, C; Presenti, L; Schurfeld, K; Stumpo, M; Tosi, P;
Indirizzi:
Univ Siena, Ist Anat & Istol Patol, I-53100 Siena, Italy Univ Siena Siena Italy I-53100 Anat & Istol Patol, I-53100 Siena, Italy
Titolo Testata:
INTERNATIONAL JOURNAL OF ONCOLOGY
fascicolo: 6, volume: 18, anno: 2001,
pagine: 1251 - 1258
SICI:
1019-6439(200106)18:6<1251:CPCDEM>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR ANGIOGENESIS; BREAST-CARCINOMA; PROGNOSTIC INDICATORS; MICROVESSEL DENSITY; BASEMENT-MEMBRANE; IV COLLAGENASE; LOW-GRADE; DYSPLASIA; INHIBITOR; ADHESION;
Keywords:
kinetics; E-cadherin; MMP2; gastric dysplasia; early gastric cancer;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Tosi, P Univ Siena, Ist Anat & Istol Patol, Via Scotte, I-53100 Siena, Italy Univ Siena Via Scotte Siena Italy I-53100 e, I-53100 Siena, Italy
Citazione:
D. Spina et al., "Cell proliferation, cell death, E-cadherin, metalloproteinase expression and angiogenesis in gastric cancer precursors and early cancer of the intestinal type", INT J ONCOL, 18(6), 2001, pp. 1251-1258

Abstract

The aim of this study was to analyse the morphological, kinetic and molecular characteristics of low-grade (LGD) and high-grade dysplasias (HDG) in comparison with intestinal metaplasia type III (IM III) and normal mucosa (NM) as well as with early gastric cancer of the intestinal type (EGC). Basedon this it was verified whether these categories are distinct, progressiveproliferative steps from IM III to LGD, HGD and EGG, according to Correa'ssequence of events. The morphology, mitotic index (MI), and the apoptotic index (AI) were assessed. The E-cadherin expression (E-Cad), matrix-metalloproteinase activity (MMP2), and the number of microvessels (NV) were also evaluated. Among the categories, MI increases from NM, to IM III and LGD, and fi om LGD to HGD and EGG, while AI continues to increase also from HGD toEGG. E-Cad decreases from NM to EGG, although not significantly from LGD to HGD; MMP2 is significantly more expressed only in EGG. Three groups are obtained by means of cluster analysis. The first group includes all the NMs and IM IIIs, all except 1 LGD, about half of HGDs, and 1 EGG. E-Cad is highly expressed, MMP2 and angiogenesis are low, the proliferative activity is low and mitoses are partly balanced by apoptoses. The second group includessome EGCs and HGDs and is characterised by a very high proliferative activity and cell death; there is an initial loss of cell adhesion, an increase of MMP2 and NV. The third group includes the majority of EGCs, but also 1 HGD: it has intermediate MI and AI, the lowest expression of E-Cad, the highest expression of MMP2 and the most numerous microvessels. These results underscore the necessity of evaluating each case individually within the samesingular category of Correa's sequence. The use of kinetic and molecular parameters in addition to the morphological analysis may give important information on the behaviour of the various lesions.

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Documento generato il 04/04/20 alle ore 12:15:53