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Titolo:
Decreased levels of precursor transforming growth factor beta(1) in human colorectal cancer
Autore:
Dimberg, J; Hugander, A; Sirsjo, A;
Indirizzi:
Univ Coll Hlth Sci, Dept Nat Sci & Biomed, S-55111 Jonkoping, Sweden Univ Coll Hlth Sci Jonkoping Sweden S-55111 d, S-55111 Jonkoping, Sweden Fac Hlth Sci, Div Cell Biol, Dept Biomed & Surg, Linkoping, Sweden Fac Hlth Sci Linkoping Sweden ol, Dept Biomed & Surg, Linkoping, Sweden Ryhov Cty Hosp, Dept Surg, Jonkoping, Sweden Ryhov Cty Hosp Jonkoping Sweden Cty Hosp, Dept Surg, Jonkoping, Sweden Karolinska Hosp, Karolinska Inst, Ctr Mol Med, Stockholm, Sweden Karolinska Hosp Stockholm Sweden a Inst, Ctr Mol Med, Stockholm, Sweden
Titolo Testata:
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
fascicolo: 6, volume: 7, anno: 2001,
pagine: 597 - 601
SICI:
1107-3756(200106)7:6<597:DLOPTG>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN-COLON-CANCER; DISEASE PROGRESSION; FACTOR BETA-1; CELL-LINE; GROWTH-FACTOR-BETA-1; CYCLOOXYGENASE-2; CARCINOMA; DIFFERENTIATION; TUMORIGENESIS; EXPRESSION;
Keywords:
TGF beta(1); protein expression; colorectal cancer;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Dimberg, J Univ Coll Hlth Sci, Dept Nat Sci & Biomed, POB 1038, S-55111 Jonkoping, Sweden Univ Coll Hlth Sci POB 1038 Jonkoping Sweden S-55111 g, Sweden
Citazione:
J. Dimberg et al., "Decreased levels of precursor transforming growth factor beta(1) in human colorectal cancer", INT J MOL M, 7(6), 2001, pp. 597-601

Abstract

Transforming growth factor (TGF) beta (1) is a growth factor with wide-ranging effects on proliferation, differentiation, immunosuppression, apoptosis and matrix remodelling. TGF beta (1) seems to have an antitumorigenic role in the gastrointestinal tract but may also be associated with the development of colorectal cancer. Initially, TGF beta (1) is produced in a latent (precursor) form in epithelial cells and then is activated by a not clearlyunderstood multistep process. In this study, we analysed precursor TGF beta (1) protein expression (n=40) and TGF beta (1) gene expression (n=49) in human colorectal adenocarcinomas and 49 normal adjacent tissue. Out of these 49 normal tissues 40 were matched. Western blot analysis revealed that the precursor TGF beta (1) protein levels were generally lower in colorectal cancerous tissue compared to adjacent noncancerous tissue (P <0.001). Furthermore, with real-time PCR our results cannot reflect a statistically significant difference in TGF beta (1) gene expression between the tumour tissueand normal tissue. These finds indicate that it is likely that there are mechanisms which control precursor TGF beta (1) protein expression by factor(s) at the level of pre-translation of the TGF beta (1) transcript and/or at the level of post-translation of the TGF beta (1) protein in the tumours. This process may be related to carcinogenesis and poses the question whether the suppression of the precursor TGF beta (1) is an early event, in vivo, in the human colorectal adenoma-carcinoma sequence.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 19:29:53