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Titolo:
Economic evaluation of universal BCG vaccination of Japanese infants
Autore:
Rahman, M; Sekimoto, M; Takamatsu, I; Hira, K; Shimbo, T; Toyoshima, K; Fukui, T;
Indirizzi:
Kyoto Univ, Grad Sch Med, Dept Gen Med & Clin Epidemiol, Sakyo Ku, Kyoto 6068507, Japan Kyoto Univ Kyoto Japan 6068507 Epidemiol, Sakyo Ku, Kyoto 6068507, Japan Osaka Prefectural Habikino Hosp, Div Pediat, Habikino City, Osaka, Japan Osaka Prefectural Habikino Hosp Habikino City Osaka Japan , Osaka, Japan
Titolo Testata:
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
fascicolo: 2, volume: 30, anno: 2001,
pagine: 380 - 385
SICI:
0300-5771(200104)30:2<380:EEOUBV>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
CALMETTE-GUERIN VACCINATION; TUBERCULOSIS; EFFICACY;
Keywords:
bacillus Calmette-Guerin (BCG); tuberculosis; Japan; vaccine; cost-effectiveness analysis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Fukui, T Kyoto Univ, Grad Sch Med, Dept Gen Med & Clin Epidemiol, Sakyo Ku, 54 Kawahara Cho, Kyoto 6068507, Japan Kyoto Univ 54 Kawahara Cho Kyoto Japan 6068507 to 6068507, Japan
Citazione:
M. Rahman et al., "Economic evaluation of universal BCG vaccination of Japanese infants", INT J EPID, 30(2), 2001, pp. 380-385

Abstract

Background The international controversy surrounding the use and effectiveness of the Bacillus Calmette-Guerin (BCG) vaccine and the low incidence oftuberculosis (TB) among Japanese children prompted this study. Methods We compared 'universal BCG vaccination' with 'no vaccination at all' using a cost-effectiveness analysis. The study population was a hypothetical cohort comprising a total of 1.2 million infants born in 1996 at locations all over Japan. A model was developed to calculate the number of TB cases prevented by the vaccination programme. Assuming 40-80% overall vaccineefficacy (64-86% for TB-meningitis) and 10 years of protection, we calculated the cost and number of immunizations required to prevent one child fromdeveloping TB, the total number of TB cases averted by vaccination and total costs required for the programme. Results Based on an assumption of flexible vaccine efficacy (40-80%), we estimated that 111-542 TB cases including 10-27 of TB-meningitis would be prevented during the 10 years after BCG vaccination among the cohort of infants born in 1996. About US$35 950-175 862 or 2125-10 399 immunizations wouldbe required to prevent one child from developing TB. Sensitivity analyses covering a wide duration of protection, incidence of TB, vaccine coverage and discount rate, revealed that other than vaccine efficacy, the cost of preventing a single case of TB is highly sensitive to the duration of BCG protection and TB incidence. Conclusion The cost per case of TB prevented is heavily dependent on vaccine efficacy and the duration of protection, and is high compared with the cost of treating one child who has developed TB.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 17/01/21 alle ore 18:17:11