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Titolo:
N-tert-butyl-alpha-phenylnitrone, a free radical scavenger with anticholinesterase activity does not improve the cognitive performance of scopolamine-challenged rats
Autore:
Milivojevic, N; Babic, K; Milatovic, D; Dettbarn, WD; Sket, D; Zivin, M;
Indirizzi:
Univ Ljubljana, Brain Res Lab, Inst Pathophysiol, Sch Med, Ljubljana 1000,Slovenia Univ Ljubljana Ljubljana Slovenia 1000 Sch Med, Ljubljana 1000,Slovenia Vanderbilt Univ, Med Ctr, Sch Med, Dept Pharmacol, Nashville, TN 37212 USAVanderbilt Univ Nashville TN USA 37212 Pharmacol, Nashville, TN 37212 USA Vanderbilt Univ, Med Ctr, Sch Med, Dept Neurol, Nashville, TN 37212 USA Vanderbilt Univ Nashville TN USA 37212 pt Neurol, Nashville, TN 37212 USA
Titolo Testata:
INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE
fascicolo: 3, volume: 19, anno: 2001,
pagine: 319 - 325
SICI:
0736-5748(200106)19:3<319:NAFRSW>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
SPIN-TRAPPING AGENTS; AMYLOID-BETA-PEPTIDE; ALZHEIMERS-DISEASE; OXIDATIVE STRESS; VITAMIN-E; ANTIOXIDANT TREATMENT; NITRONE PBN; AGED RATS; BRAIN; PROTEINS;
Keywords:
free radical scavenger; anticholinesterase activity; scopolamine-challenged rats;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Zivin, M Univ Ljubljana, Brain Res Lab, Inst Pathophysiol, Sch Med, Zaloska 4, Ljubljana 1000, Slovenia Univ Ljubljana Zaloska 4 Ljubljana Slovenia 1000 1000, Slovenia
Citazione:
N. Milivojevic et al., "N-tert-butyl-alpha-phenylnitrone, a free radical scavenger with anticholinesterase activity does not improve the cognitive performance of scopolamine-challenged rats", INT J DEV N, 19(3), 2001, pp. 319-325

Abstract

Reversible inhibitors of acetylcholinesterase improve spatial learning andmemory in animal models of cognitive impairment. Here we investigate if the beneficial effects of Free radical scavenger N-tert-butyl-alpha-phenylnitrone (PBN) on cognitive performance could be explained by its recently discovered anticholinesterase activity. Morris water maze experiment was performed to examine the effect of PBN on the impairment of spatial learning and memory induced by the antagonist of cholinergic muscarinic transmission scopolamine. In situ hybridization histochemistry experiment was performed to study its effects on the induction of immediate early gene expression (c-fos, c-jun) by dopamine D1 receptor agonist SKF-82958 and on the augmentationof the SKF-83958-induced expression of these genes by scopolamine. In bothexperiments. the effects of PEN were compared to the effects of reversibleanticholinesterase physostigmine. We found that physostigmine but not PEN significantly, reversed the cognitive impairment in scopolamine-challenged rats, prevented the induction of c-fos and c-jun mRNAs by SKF-82958 and attenuated the augmentation of the SKF-87958-induced expression of these genesby scopolamine. The present experiments did not reveal a significant in vivo anticholinesterase activity of PEN. (C) 2001 ISDN. Published by ElsevierScience Ltd. All rights reserved.

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Documento generato il 31/03/20 alle ore 03:17:27