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Titolo:
Early onset of glutamatergic and GABAergic synaptic activity in the visuallayers of the rodent superior colliculus
Autore:
Juttner, R; Henneberger, C; Grantyn, R; Rothe, T;
Indirizzi:
Johannes Muller Inst Physiol, Charite, D-10117 Berlin, Germany Johannes Muller Inst Physiol Berlin Germany D-10117 0117 Berlin, Germany
Titolo Testata:
INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE
fascicolo: 3, volume: 19, anno: 2001,
pagine: 255 - 261
SICI:
0736-5748(200106)19:3<255:EOOGAG>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSTNATAL-DEVELOPMENT; OPTIC-NERVE; FETAL RATS; NEURONS; RECEPTORS; CURRENTS; INVITRO; PATHWAY; MOUSE; BRAIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Rothe, T Johannes Muller Inst Physiol, Charite, Tucholskystr 2, D-10117 Berlin, Germany Johannes Muller Inst Physiol Tucholskystr 2 Berlin Germany D-10117
Citazione:
R. Juttner et al., "Early onset of glutamatergic and GABAergic synaptic activity in the visuallayers of the rodent superior colliculus", INT J DEV N, 19(3), 2001, pp. 255-261

Abstract

During postnatal development. the retinocollicular pathway undergoes activity-dependent refinement, resulting in the precise retinotopic map seen in adults. Previous studies established that retinal efferents reach the mouseSuperior colliculus (SC) by embryonic day 16. Morphologically, synapses were found in the rat SC before birth. As part of an extended project aimed at understanding the development of synaptic transmission in the visual layers of the SC, we report here the presence of functionally active synapses immediately after birth. Circuit activity in mouse SC neurons was detected in horizontal slices of the visual layers using cell-attached voltage clamp. The spontaneous discharge of action potentials was abolished by glutamatergic blockers and facilitated by bicuculline, showing that circuit activity is based on synaptic transmission and that the action of gamma -aminobutyric acid is inhibitory. Using whole-cell voltage clamp, spontaneous glutamatergic postsynaptic currents as well as miniature GABAergic postsynaptic currents were recorded on postnatal day 1. Excitatory and inhibitory postsynaptic currents could also be evoked by electrical stimulation. Glutamatergic postsynaptic currents comprised both (S)-alpha -amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid and N-methyl-D-aspartate receptor-mediated components. The early function of glutamatergic and GABAergic synaptic transmission in the visual layers of SC suggests that SC neurons are able to process information originating From retinal axons immediately after birth. (C) 2001 ISDN. Published by Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 18:05:18