Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Development of long-lasting potentiation effects in the dentate gyrus during pentylenetetrazol kindling
Autore:
Ruthrich, H; Grecksch, G; Krug, M;
Indirizzi:
Otto Von Guericke Univ, Fac Med, Inst Pharmacol & Toxicol, D-39120 Magdenburg, Germany Otto Von Guericke Univ Magdenburg Germany D-39120 20 Magdenburg, Germany
Titolo Testata:
INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE
fascicolo: 3, volume: 19, anno: 2001,
pagine: 247 - 254
SICI:
0736-5748(200106)19:3<247:DOLPEI>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
METHYL-D-ASPARTATE; TERM POTENTIATION; HIPPOCAMPAL-FORMATION; GLUTAMATE BINDING; RAT HIPPOCAMPUS; NMDA RECEPTORS; GRANULE CELLS; LOW-FREQUENCY; EXPRESSION; EPILEPSY;
Keywords:
chemical kindling; pentylenetetrazol; rat; dentate gyrus; field potentials; kindling-induced potentiation; learning;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
44
Recensione:
Indirizzi per estratti:
Indirizzo: Ruthrich, H Otto Von Guericke Univ, Fac Med, Inst Pharmacol & Toxicol, Leipziger Str 44, D-39120 Magdenburg, Germany Otto Von Guericke Univ LeipzigerStr 44 Magdenburg Germany D-39120
Citazione:
H. Ruthrich et al., "Development of long-lasting potentiation effects in the dentate gyrus during pentylenetetrazol kindling", INT J DEV N, 19(3), 2001, pp. 247-254

Abstract

In the present study kindling was induced in rats by repeated intraperitoneal injection of pentylenetetrazol (PTZ) once every 48 h. The resulting seizure stages were registered after each PTZ application. The development of PTZ-induced kindling and the time course of possible potentiation effects in the dentate gyrus were examined. The efficacy of perforant pathway transmission to the granule cells was tested in every second kindling session by measuring the monosynaptic evoked field potentials recorded in the dentate gyrus following single test stimuli of the perforant pathway at different rimes after PTZ injection in freely moving animals. The data suggest that establishment of a PTZ kindling is associated with the development of long-lasting potentiation of the field potentials. After completion of kindling itwas demonstrated that kindled rats also show a diminished learning performance. The relationship between the development of potentiation phenomena inhippocampal substructures and learning impairment is discussed. (C) 2001 ISDN. Published by Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 19:02:45