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Titolo:
Quantitative aspects of stress-induced immunomodulation
Autore:
Pruett, SB;
Indirizzi:
Louisiana State Univ, Hlth Sci Ctr, Dept Cellular Biol & Anat, Shreveport,LA 71130 USA Louisiana State Univ Shreveport LA USA 71130 nat, Shreveport,LA 71130 USA
Titolo Testata:
INTERNATIONAL IMMUNOPHARMACOLOGY
fascicolo: 3, volume: 1, anno: 2001,
pagine: 507 - 520
SICI:
1567-5769(200103)1:3<507:QAOSI>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
KILLER-CELL-ACTIVITY; CORTICOSTEROID-BINDING GLOBULIN; PITUITARY-ADRENAL AXIS; ETHANOL-INDUCED SUPPRESSION; B6C3F1 FEMALE MICE; MOUSE MODEL; RESTRAINT STRESS; BINGE DRINKING; IMMUNE-SYSTEM; ENDOGENOUS GLUCOCORTICOIDS;
Keywords:
immunomodulation; immunosuppression; neuroendocrine-immune interaction;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
106
Recensione:
Indirizzi per estratti:
Indirizzo: Pruett, SB Louisiana State Univ, Hlth Sci Ctr, Dept Cellular Biol & Anat, 1501 Kings Highway, Shreveport, LA 71130 USA Louisiana State Univ 1501 Kings Highway Shreveport LA USA 71130
Citazione:
S.B. Pruett, "Quantitative aspects of stress-induced immunomodulation", INT IMMUNO, 1(3), 2001, pp. 507-520

Abstract

Recent studies indicate that neuroendocrine-immune interactions can cause sufficient immunosuppression to adversely affect human health, but quantitative relationships between tress-related hormones or neurotransmitters and immune function have nor been well documented. The mechanisms of stress-induced immunomodulation cannot be fully understood solely by identifying the hormones, neurotransmitters. and cytokines involved. Quantitative relationships and interactions must also be understood. Depending on the nature and duration of the stressor and the immunological parameter under investigation, stress responses can enhance. have no effect. or suppress immunological parameters. These quantitative relationships have implications with regard to safety assessment of drugs and chemicals and with regard to potential development of pharmacological interventions to ameliorate some of the immunosuppressive effects of stress. This review describes selected studies that relate the quantity and duration of exposure to stress-related neuroendocrine mediators to modulation of the immune system. These studies provide a useful starting point, but they also illustrate how much work remains to achieve a fully integrated qualitative and quantitative understanding of stress-induced immunomodulation. (C) 2001 Elsevier Science B.V. All rights reserved.

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Documento generato il 10/04/20 alle ore 16:07:29