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Titolo:
Functions of anaphylatoxin C5a in rat liver: direct and indirect actions on nonparenchymal and parenchymal cells
Autore:
Schieferdecker, HL; Schlaf, G; Jungermann, K; Gotze, O;
Indirizzi:
Univ Gottingen, Inst Biochem & Mol Zellbiol, D-37073 Gottingen, Germany Univ Gottingen Gottingen Germany D-37073 iol, D-37073 Gottingen, Germany Univ Gottingen, Immunol Abt, D-37075 Gottingen, Germany Univ Gottingen Gottingen Germany D-37075 Abt, D-37075 Gottingen, Germany
Titolo Testata:
INTERNATIONAL IMMUNOPHARMACOLOGY
fascicolo: 3, volume: 1, anno: 2001,
pagine: 469 - 481
SICI:
1567-5769(200103)1:3<469:FOACIR>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
SINUSOIDAL ENDOTHELIAL-CELLS; TUMOR-NECROSIS-FACTOR; ACUTE-PHASE RESPONSE; MESSENGER-RNA EXPRESSION; HEPATIC STELLATE CELLS; KUPFFER CELLS; PROTEIN-SYNTHESIS; DIFFERENTIAL EXPRESSION; PROSTANOID RELEASE; EPITHELIAL-CELLS;
Keywords:
C5a receptor expression; cell-cell communication; hepatic defense reactions; inflammation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
84
Recensione:
Indirizzi per estratti:
Indirizzo: Schieferdecker, HL Univ Gottingen, Inst Biochem & Mol Zellbiol, Humboldtallee 23, D-37073 Gottingen, Germany Univ Gottingen Humboldtallee 23 Gottingen Germany D-37073
Citazione:
H.L. Schieferdecker et al., "Functions of anaphylatoxin C5a in rat liver: direct and indirect actions on nonparenchymal and parenchymal cells", INT IMMUNO, 1(3), 2001, pp. 469-481

Abstract

Growing evidence obtained in recent years indicates that anaphylatoxin C5areceptors (C5aR) are not restricted to myeloid cells but are also expressed on nonmyeloid cells in different tissues such as brain, lung, skin and liver. In contrast to its well-defined systemic functions, the actions of anaphylatoxins in these organs are poorly characterized. The liver can be a primary target organ for the C5a anaphylatoxin since the liver is directly connected to the gut, via the mesenteric veins and portal vein which is a main source of complement activating lipopolysaccharides (LPS). In the normal rat liver, the C5aR is only expressed by nonparenchymal cells, i.e. strongly by Kupffer cells (KC) and hepatic stellate cells (HSC) and weakly by sinusoidal endothelial cells (SEC), bur not expressed by the parenchymal hepatocytes (HC). Accordingly, direct effects of C5a were only found in the C5aR-expressing KC and HSC: C5a induced thr release of prostanoids from KC and HSC and enhanced the UPS-dependent release of interleukin-6 from KC, These soluble mediators indirectly influenced effector functions of the C5aR-free HC. C5a enhanced the glycogen phosphorylase activity and thus the glucose output from HC indirectly via prostanoids released from KC and HSC. Glucose can serve as an energy substrate as well as an electron donor for the synthesis of reactive oxygen intermediates by KC. Moreover, C5a also enhanced transcription of the gene for the type-2 acute phase protein alpha (2)-macroglobulin in HC indirectly by increasing LPS-dependent IL-6 release from KC. Under pathological conditions. C5aR was found to be upregulated in various organs including the liver. Simulation of inflammatory conditions by treatment of rats with IL-6, a main inflammatory mediator in the liver, caused a de novo expression of functional C5aR in HC. In livers of IL-6-treated rats, C5a initiated glucose output from HC and perhaps other HC-specific defense reactions directly without the intervention of soluble mediators from nonparenchymal cells. (C) 2001 Elsevier Science B.V, All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/04/20 alle ore 12:11:52