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Titolo:
Activation of the lectin complement pathway by ficolins
Autore:
Matsushita, M; Endo, Y; Hamasaki, N; Fujita, T;
Indirizzi:
Fukushima Univ Med, Dept Biochem, Sch Med, Fukushima 9601295, Japan Fukushima Univ Med Fukushima Japan 9601295 Med, Fukushima 9601295, Japan Kyushu Univ, Grad Sch Med Sci, Dept Clin Chem & Lab Med, Fukuoka 8128582, Japan Kyushu Univ Fukuoka Japan 8128582 Chem & Lab Med, Fukuoka 8128582, Japan
Titolo Testata:
INTERNATIONAL IMMUNOPHARMACOLOGY
fascicolo: 3, volume: 1, anno: 2001,
pagine: 359 - 363
SICI:
1567-5769(200103)1:3<359:AOTLCP>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
MANNOSE-BINDING LECTIN; SERINE-PROTEASE; FIBRINOGEN-LIKE; HAKATA ANTIGEN; COLLAGEN-LIKE; HUMAN PLASMA; P35; PROTEINS; CLONING; FAMILY;
Keywords:
complement; lectin pathway; ficolins; MBL; MASP;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Matsushita, M Fukushima Univ Med, Dept Biochem, Sch Med, 1 Higariga Oka, Fukushima 9601295, Japan Fukushima Univ Med 1 Higariga Oka Fukushima Japan 9601295 n
Citazione:
M. Matsushita et al., "Activation of the lectin complement pathway by ficolins", INT IMMUNO, 1(3), 2001, pp. 359-363

Abstract

Mannose-binding lectin (MBL), a serum lectin specific for mannose or N-acetylglucosamine (GlcNAc), which contains both a collagen-like domain and a carbohydrate-recognition domain (CRD). plays a role in innate immunity by acting as an opsonin and activating complement in association with MEL-associated serine protease (MASP) via the lectin pathway. Another type of GlcNAc-binding lectins termed "ficolins" exist in serum. They are characterized bythe presence of both a collagen-like domain and a fibrinogen-like domain. Investigations of two types Of human serum ficolins, ficolin/P35 and Hakataantigen, revealed that they are associated with MASPs and sMAP, a truncated protein of MASP-2, and activate complement. These findings indicate that,like MEL. serum ficolins an collagenous lectins capable of activating the lectin pathway and thus have a role in innate immunity. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 01:41:41