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Titolo:
Dexamethasone inhibits invasion of murine T cells through cultured fibroblastic monolayers
Autore:
Baus, E; Andris, F; Dewit, J; Van der Taelen, I; De Baetselier, P; Urbain, J; Leo, O; Verschuerern, H;
Indirizzi:
Free Univ Brussels, Dept Biol Mol, Physiol Anim Lab, B-6041 Gosselies, Belgium Free Univ Brussels Gosselies Belgium B-6041 b, B-6041 Gosselies, Belgium Inst Pasteur, Brussels, Belgium Inst Pasteur Brussels BelgiumInst Pasteur, Brussels, Belgium Free Univ Brussels, B-1640 Rhode St Genese, Belgium Free Univ Brussels Rhode St Genese Belgium B-1640 ode St Genese, Belgium
Titolo Testata:
INTERNATIONAL IMMUNOPHARMACOLOGY
fascicolo: 4, volume: 1, anno: 2001,
pagine: 785 - 793
SICI:
1567-5769(200104)1:4<785:DIIOMT>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
IN-VITRO INVASIVENESS; F-ACTIN CONTENT; L-SELECTIN; LYMPHOMA-CELLS; TRANSENDOTHELIAL MIGRATION; INTERCELLULAR-ADHESION; LYMPHOCYTES; RECEPTOR; EXPRESSION; NEUTROPHILS;
Keywords:
dexamethasone; lymphoma; invasion; metastasis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Baus, E Free Univ Brussels, Dept Biol Mol, Physiol Anim Lab, Rue Prof Jeener & Brachet 12, B-6041 Gosselies, Belgium Free Univ Brussels Rue Prof Jeener & Brachet 12 Gosselies Belgium B-6041
Citazione:
E. Baus et al., "Dexamethasone inhibits invasion of murine T cells through cultured fibroblastic monolayers", INT IMMUNO, 1(4), 2001, pp. 785-793

Abstract

Despite the wide clinical use of glucocorticoids in the chemotherapy of leukaemia and lymphoma. there have been limited efforts at understanding the effects of these hormones on metastasis formation. The purpose of this study was to investigate the effects of glucocorticoids on the tissue-infiltrating capability of lymphoid cells. Using an in vitro invasion assay, we found that dexamethasone, a synthetic glucocorticoid analogue, inhibited the invasion of a murine T-cell hybridoma through a monolayer of fibroblast-like cells. Even low doses of dexamethasone were effective at inhibiting cellular transmigration (EC50 = 0.4 nM). A maximal decrease was observed after an overnight culture in the presence of dexamethasone. The effect persisted for at least 24 h after removal of the drug and required the binding of the hormone to its intracellular glucocorticoid receptor. Our results suggest that the decreased invasiveness of dexamethasone-treated cells is not the consequence of reduced motility or deficient production of an autocrine factorrequired for cell migration. This in vitro study suggests that glucocorticoids may act to reduce dissemination of lymphoma cells in vivo. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 05:37:01