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Titolo:
Vaccination with MCP-1 cDNA transfectant on human malignant glioma in nudemice induces migration of monocytes and NK cells to the tumor
Autore:
Nagai, M; Masuzawa, T;
Indirizzi:
Jichi Med Sch, Dept Neurol Surg, Minami Kawachi, Tochigi 3290498, Japan Jichi Med Sch Minami Kawachi Tochigi Japan 3290498 Tochigi 3290498, Japan
Titolo Testata:
INTERNATIONAL IMMUNOPHARMACOLOGY
fascicolo: 4, volume: 1, anno: 2001,
pagine: 657 - 664
SICI:
1567-5769(200104)1:4<657:VWMCTO>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
LASTING ANTITUMOR IMMUNITY; CHEMOATTRACTANT PROTEIN-1; GENE-TRANSFER; REDUCED TUMORIGENICITY; GAMMA-INTERFERON; EXPRESSION; CANCER; INTERLEUKIN-4; INFILTRATION; SUPPRESSION;
Keywords:
MCP-1; tumor vaccine; monocyte; NK cell;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Nagai, M Jichi Med Sch, Dept Neurol Surg, 3311-1 Yakushiji, Minami Kawachi, Tochigi3290498, Japan Jichi Med Sch 3311-1 Yakushiji Minami Kawachi Tochigi Japan 3290498
Citazione:
M. Nagai e T. Masuzawa, "Vaccination with MCP-1 cDNA transfectant on human malignant glioma in nudemice induces migration of monocytes and NK cells to the tumor", INT IMMUNO, 1(4), 2001, pp. 657-664

Abstract

Recently, studies on vaccination with tumor cells genetically engineered to produce monocyte chemoattractant protein-1 (MCP-1) have provided some encouragement. These studies have shown infiltration of certain types of lymphocytes at the tumor site. However, natural killer (NK) cells have not yet been assessed, We obtained a human malignant glioma cell line producing human MCP-1 constitutively by transfection of MCP-1 cDNA. We then test the effect of vaccination with the MCP-1 transfectant on nude mice. Although vaccination with MCP-1 transfectant did not reduce the tumor in our study, it wasassociated with the infiltration of large numbers of NK cells and monocytes at the tumor site. The site of vaccination also showed large numbers of monocytes. NK cells were detected with anti-asialo GM1 antibody, and monocytes were detected immunohistochemically with F4/80. We assumed that infiltrating monocytes at the site of vaccination could promote the infiltration ofmonocytes and NK cells into the tumor site without T-cell mediated transduction because the host lacked T-cell function. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/02/20 alle ore 02:57:11