Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Coordination of chemokine and adhesion systems in intratumoral T cell migration responsible for the induction of tumor regression
Autore:
Fujiwara, H; Hamaoka, T;
Indirizzi:
Osaka Univ, Grad Sch Med, Dept Oncol, Biomed Res Ctr, Suita, Osaka 5650871, Japan Osaka Univ Suita Osaka Japan 5650871 Res Ctr, Suita, Osaka 5650871, Japan
Titolo Testata:
INTERNATIONAL IMMUNOPHARMACOLOGY
fascicolo: 4, volume: 1, anno: 2001,
pagine: 613 - 623
SICI:
1567-5769(200104)1:4<613:COCAAS>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
IFN-GAMMA PRODUCTION; DENDRITIC CELLS; CHEMOTACTIC RESPONSIVENESS; LYMPHOCYTE RECIRCULATION; LEUKOCYTE EMIGRATION; RECEPTOR EXPRESSION; INTERFERON-GAMMA; TRAFFIC SIGNALS; INTERLEUKIN-12; IL-12;
Keywords:
T cell migration; interleukin-12; chemokines; chemokine receptors; adhesion molecules;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
57
Recensione:
Indirizzi per estratti:
Indirizzo: Fujiwara, H Osaka Univ, Grad Sch Med, Dept Oncol, Biomed Res Ctr, 2-2 Yamadaoka, Suita, Osaka 5650871, Japan Osaka Univ 2-2 Yamadaoka Suita Osaka Japan 5650871 0871, Japan
Citazione:
H. Fujiwara e T. Hamaoka, "Coordination of chemokine and adhesion systems in intratumoral T cell migration responsible for the induction of tumor regression", INT IMMUNO, 1(4), 2001, pp. 613-623

Abstract

T cell migration into tumor masses is critical to the process of immunologically induced rumor regression. Like other lymphoid populations, T cells are recruited to inflammatory sites depending on the interaction of T cell integrin receptors with their ligands expressed on vasculature. It is increasingly becoming evident that the adhesive capacity of integrins is upregulated by signals from chemokine receptors. A model of intratumoral T cell migration has been established using IL-12 to induce tumor regression. Focusing on this particular model, we review how IL-12 works to upregulate the expression and/or function of chemokines/chemokine receptors as well as adhesion molecules and to induct collaboration between chemokine and adhesion systems. This article will also describe why such an IL-12-induced activation of chemokine and adhesion systems leads to T cell-mediated tumor regressionin some tumor models, but not in others, (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 19:02:34