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Titolo:
Molecular medicine in the 21st century
Autore:
Semsarian, C; Seidman, CE;
Indirizzi:
Harvard Univ, Sch Med, Dept Genet, Boston, MA 02115 USA Harvard Univ Boston MA USA 02115 ch Med, Dept Genet, Boston, MA 02115 USA Harvard Univ, Sch Med, Howard Hughes Med Inst, Boston, MA 02115 USA Harvard Univ Boston MA USA 02115 rd Hughes Med Inst, Boston, MA 02115 USA Brigham & Womens Hosp, Boston, MA 02115 USA Brigham & Womens Hosp Boston MA USA 02115 mens Hosp, Boston, MA 02115 USA
Titolo Testata:
INTERNAL MEDICINE JOURNAL
fascicolo: 1, volume: 31, anno: 2001,
pagine: 53 - 59
SICI:
1444-0903(200101/02)31:1<53:MMIT2C>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
FAMILIAL HYPERTROPHIC CARDIOMYOPATHY; SUDDEN CARDIAC DEATH; GENE-THERAPY; CLINICAL MANIFESTATIONS; PROGNOSTIC IMPLICATIONS; PATHO-PHYSIOLOGY; MUTATIONS; DISEASE; INTERRELATIONS; RESTENOSIS;
Keywords:
DNA; genetics; Human Genome Project; medicine; molecular;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
47
Recensione:
Indirizzi per estratti:
Indirizzo: Semsarian, C Harvard Univ, Sch Med, Dept Genet, 200 Longwood Ave, Boston, MA 02115 USA Harvard Univ 200 Longwood Ave Boston MA USA 02115 A 02115 USA
Citazione:
C. Semsarian e C.E. Seidman, "Molecular medicine in the 21st century", INTERN M J, 31(1), 2001, pp. 53-59

Abstract

When Watson and Crick proposed the double helix model for DNA structure ina 2 page Nature article in 1953, no one could have predicted the enormous impact this finding would have on the study of human disease. Over the lastdecade in particular, major advances have been made in our understanding of both normal biological processes and basic molecular mechanisms underlying a variety of medical diseases. Knowledge obtained from basic cellular, molecular and genetic studies has enabled the development of strategies for the modification, prevention and potential cure of human diseases. This brief overview focuses on the enormous impact molecular studies have had on various aspects of medicine. The inherited cardiac disorder hypertrophic cardiomyopathy is used here as a model to illustrate how molecular studies have not only redefined 'gold standards' for diagnosis, but have also influencedmanagement approaches, increased our understanding of fundamental disease-causing mechanisms and identified potential targets for therapeutic intervention. The near-completion of the Human Genome Project, which identifies the 3.2 billion base pairs that comprise the human genome (the so-called 'Book of Life'), has exponentially heightened the focus on the importance of molecular studies and how such studies will impact on various aspects of medicine in the 21st century.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 22:21:27