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Titolo:
Quadriceps muscle wasting persists 5 months after total hip arthroplasty for osteoarthritis of the hip: a pilot study
Autore:
Reardon, K; Galea, M; Dennett, X; Choong, P; Byrne, E;
Indirizzi:
St Vincents Hosp, Melbourne Neuromuscular Res Inst, Fitzroy, Vic 3065, Australia St Vincents Hosp Fitzroy Vic Australia 3065 Fitzroy, Vic 3065, Australia St Vincents Hosp, Dept Orthopaed, Fitzroy, Vic 3065, Australia St VincentsHosp Fitzroy Vic Australia 3065 Fitzroy, Vic 3065, Australia Univ Melbourne, Sch Physiotherapy, Melbourne, Vic, Australia Univ Melbourne Melbourne Vic Australia herapy, Melbourne, Vic, Australia Univ Melbourne, State Neuropathol Serv, Melbourne, Vic, Australia Univ Melbourne Melbourne Vic Australia l Serv, Melbourne, Vic, Australia
Titolo Testata:
INTERNAL MEDICINE JOURNAL
fascicolo: 1, volume: 31, anno: 2001,
pagine: 7 - 14
SICI:
1444-0903(200101/02)31:1<7:QMWP5M>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN SKELETAL-MUSCLE; LOWER-EXTREMITY; IMMOBILIZATION; STRENGTH; INCREASES; ATROPHY; AGE;
Keywords:
disuse muscle atrophy; fibre type analysis; muscle strength; muscle ultrasound; osteoarthritis of hip;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Reardon, K St Vincents Hosp, Melbourne Neuromuscular Res Inst, 41 VictoriaParade, Fitzroy, Vic 3065, Australia St Vincents Hosp 41 Victoria Parade Fitzroy Vic Australia 3065
Citazione:
K. Reardon et al., "Quadriceps muscle wasting persists 5 months after total hip arthroplasty for osteoarthritis of the hip: a pilot study", INTERN M J, 31(1), 2001, pp. 7-14

Abstract

Aims: To determine whether additional muscle fibre wasting of the ipsilateral vastus lateralis muscle occurs in the early postoperative period after total hip arthroplasty for osteoarthritis of the hip and whether there is an improvement in preoperative measures of quadriceps muscle thickness, strength, pain and function over a 5-month postoperative period. Methods: Twelve patients had ipsilateral needle quadriceps biopsy for muscle morphology and bilateral quadriceps muscle thickness ultrasound preoperatively, 5 days and 4 weeks postoperatively and a further muscle thickness measurement at 5 months. Seven additional patients and five age-matched control subjects had bilateral quadriceps muscle ultrasound thickness preoperatively, 6 weeks and 5 months postoperatively, with assessment of quadriceps muscle dynamometry, pain scores and Timed Up and Go (TUG) test. Results: Preoperatively, all 19 patients demonstrated significant atrophy of the ipsilateral compared with the contralateral quadriceps muscle (P = 1.8 x 10(-7)) on muscle ultrasound, which persisted at 5 months follow up (P= 0.009). Muscle morphology preoperatively showed type 2A and 2B muscle fibre atrophy on needle muscle biopsy, with further atrophy of all three fibre types (P = 0.029) at 5 days postoperatively associated with a fibre type shift from type I to 2A fibres (P = 0.0011) at 1 month. There was improvement in hip pain postoperatively and a significant improvement in the TUG test (P = 0.007). However, there was no improvement in muscle strength on dynamometry. Conclusions: There is significant ipsilateral quadriceps atrophy and weakness with 2A and 2B fibre atrophy preoperatively in patients with osteoarthritis of the hip with exacerbation and further atrophy of all three fibre types 5 days postoperatively. Postoperative follow up showed that the reduction in ipsilateral quadriceps muscle thickness persisted at 5 months despitephysical rehabilitation. Patients did note significant improvement in painpostoperatively and improvement on functional assessment with the TUG test. Other therapeutic strategies may have to be developed to reverse disuse muscle atrophy.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 21:43:37