Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Leptin acts in the central nervous system to produce dose-dependent changes in arterial pressure
Autore:
Correia, MLG; Morgan, DA; Sivitz, WI; Mark, AL; Haynes, WG;
Indirizzi:
Univ Iowa, Dept Internal Med, Iowa City, IA 52242 USA Univ Iowa Iowa CityIA USA 52242 pt Internal Med, Iowa City, IA 52242 USA Univ Iowa, Ctr Cardiovasc, Specialized Ctr Res Hypertens Genet, Iowa City,IA 52242 USA Univ Iowa Iowa City IA USA 52242 Hypertens Genet, Iowa City,IA 52242 USA Vet Affairs Med Ctr, Iowa City, IA 52242 USA Vet Affairs Med Ctr Iowa City IA USA 52242 d Ctr, Iowa City, IA 52242 USA
Titolo Testata:
HYPERTENSION
fascicolo: 3, volume: 37, anno: 2001,
pagine: 936 - 942
SICI:
0194-911X(200103)37:3<936:LAITCN>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
BLOOD-PRESSURE; OBESE GENE; BODY-WEIGHT; NORMAL RATS;
Keywords:
hormones; sodium; obesity; hypertension, arterial; sympathetic nervous system;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Haynes, WG Univ Iowa, Dept Internal Med, Iowa City, IA 52242 USA Univ Iowa Iowa City IA USA 52242 Med, Iowa City, IA 52242 USA
Citazione:
M.L.G. Correia et al., "Leptin acts in the central nervous system to produce dose-dependent changes in arterial pressure", HYPERTENSIO, 37(3), 2001, pp. 936-942

Abstract

Systemic leptin increases energy expenditure through sympathetic mechanisms, decreases appetite, and increases arterial pressure. We tested the hypothesis that the presser action of leptin is mediated by the central nervous system. The interaction of dietary salt with leptin was also studied. Leptin was infused for 2 to 4 weeks into the third cerebral ventricle of Sprague-Dawley rats. Arterial pressure was measured by radiotelemetry. To control for the effects of leptin on body weight, vehicle-treated rats were pair-fed to the leptin group. Intracerebroventricular infusion of leptin at 200 ng/h in salt-depleted rats caused a reduction in food intake, weight loss, tachycardia, and decreased arterial pressure. Leptin at 1000 ng/h caused further reduction in food intake, weight loss, and tachycardia and prevented the hypotensive effect of weight loss observed in pair-fed, vehicle-treated animals. Intracerebroventricular leptin at 1000 ng/h in high-salt-fed rats also caused a sustained presser response (+3+/-1 mm Hg), but high-salt intake did not potentiate the presser effect of leptin. Intracerebroventricular leptin potentiated the presser effect of air-jet stress. Intravenous administration of the same dose of leptin (1000 ng/h) did not change weight or arterial pressure, suggesting a direct central nervous system action. In contrast, a high dose of intravenous leptin (18 000 ng/h) caused weight loss and prevented the depressor effect of weight loss. In conclusion, this study demonstrates that high-dose leptin increases arterial pressure and heart rate through central neural mechanisms but leptin does not enhance salt sensitivity of arterial pressure. Leptin appears to oppose the depressor effect of weight loss.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 12:56:06