Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Effects of environmental antiandrogens on reproductive development in experimental animals
Autore:
Gray, LE; Ostby, J; Furr, J; Wolf, CJ; Lambright, C; Parks, L; Veeramachaneni, DN; Wilson, V; Price, M; Hotchkiss, A; Orlando, E; Guillette, L;
Indirizzi:
US EPA, NHEERL, ORD, RTD,Endocrinol Branch, Res Triangle Pk, NC 27711 USA US EPA Res Triangle Pk NC USA 27711 Branch, Res Triangle Pk, NC 27711 USA Colorado State Univ, Dept Anim Reprod & Biotechnol, Ft Collins, CO 80523 USA Colorado State Univ Ft Collins CO USA 80523 nol, Ft Collins, CO 80523 USA US EPA, NCSU, Cooperat Res Program, Gainesville, FL USA US EPA Gainesville FL USA CSU, Cooperat Res Program, Gainesville, FL USA Univ Florida, Dept Zool, Gainesville, FL 32611 USA Univ Florida Gainesville FL USA 32611 ept Zool, Gainesville, FL 32611 USA
Titolo Testata:
HUMAN REPRODUCTION UPDATE
fascicolo: 3, volume: 7, anno: 2001,
pagine: 248 - 264
SICI:
1355-4786(200105/06)7:3<248:EOEAOR>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANDROGEN-RECEPTOR ANTAGONIST; IN-UTERO EXPOSURE; ALLIGATORS ALLIGATOR-MISSISSIPPIENSIS; MALE SEXUAL DEVELOPMENT; DOSE-RESPONSE ANALYSIS; EGGSHELL GLAND MUCOSA; N-BUTYL PHTHALATE; LONG-EVANS RATS; LACTATIONAL EXPOSURE; DI-(2-ETHYLHEXYL) PHTHALATE;
Keywords:
antiandrogens; pesticides; phthalates; pulp mill effluent; sexual differentiation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
182
Recensione:
Indirizzi per estratti:
Indirizzo: Gray, LE US EPA, NHEERL, ORD, RTD,Endocrinol Branch, MD-72, Res Triangle Pk, NC 27711 USA US EPA MD-72 Res Triangle Pk NC USA 27711 iangle Pk, NC 27711 USA
Citazione:
L.E. Gray et al., "Effects of environmental antiandrogens on reproductive development in experimental animals", HUM REP UPD, 7(3), 2001, pp. 248-264

Abstract

Chemicals that act as androgen receptor (AR) agonists and antagonists or inhibit fetal steroidogenesis can induce reproductive malformations in humans and laboratory animals. Several environmental chemicals disrupt development in: rats and/or rabbits at fetal concentrations at, or near, exposure levels seen in some segments of the human population. In rats, fetal tissues concentrations of 10-20 p,p,m. of the DDT metabolite, p,p ' -DDE, are correlated with reproductive abnormalities in male offspring. These concentrations are similar to those measured in first-trimester human fetal tissues in the late 1960s. The pesticides vinclozolin, procymidone, linuron and DDT are AR antagonists;: They reduce male rat anogenital distance, and induce areolas at relatively low dosages, Hypospadias, agenesis of the sex accessory tissues and retained nipples are seen in the middle dosages, while undescended testes and epididymal agenesis are seen in the highest doses. Phthalateesters (PE) inhibit testosterone synthesis during fetal life, but do not appear to be AR antagonists. Prenatal administration of a single low dose ofdioxin (50-1000 ng TCDD/kg) alters the differentiation of androgen-dependent tissues at p.p.t. concentrations, but the mechanism of action likely involves interaction with a hormone-like nuclear transcription factor, the hormone-like receptor AhR, rather than AW, p,p ' -DDT and p,p ' -DDE, vinclozolin and di-n-butyl phthalate affect reproductive function in rabbits when administered during prenatal and/or neonatal life. Cryptorchidism and carcinoma in situ-like (CIS) testicular lesions were seen in male rabbits treatedduring development with p,p ' -DDT or p,p ' -DDE, Extrapolation of effectsfrom rodents to humans would be enhanced if future studies incorporate determination of tissue concentrations of the active metabolites. Knowledge ofthe tissue concentrations of the active toxicants also would provide an important link to in-vitro studies, which provide more useful mechanistic information when they are executed at relevant concentrations.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/07/20 alle ore 00:48:50