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Titolo:
Neonatal exposure to potent and environmental oestrogens and abnormalitiesof the male reproductive system in the rat: evidence for importance of theandrogen-oestrogen balance and assessment of the relevance to man
Autore:
Williams, K; McKinnell, C; Saunders, PTK; Walker, M; Fisher, JS; Turner, KJ; Atanassova, N; Sharpe, RM;
Indirizzi:
MRC, Human Reprod Sci Unit, Ctr Reprod Biol, Edinburgh EH3 9ET, Midlothian, Scotland MRC Edinburgh Midlothian Scotland EH3 9ET h EH3 9ET, Midlothian, Scotland
Titolo Testata:
HUMAN REPRODUCTION UPDATE
fascicolo: 3, volume: 7, anno: 2001,
pagine: 236 - 247
SICI:
1355-4786(200105/06)7:3<236:NETPAE>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
ESTROGEN-RECEPTOR-BETA; BISPHENOL-A; ORGAN DEVELOPMENT; CELL DEVELOPMENT; MARMOSET MONKEY; EXCURRENT DUCTS; RETE TESTIS; ADULT-RAT; IN-UTERO; EXPRESSION;
Keywords:
androgen; oestrogen balance; androgen receptors; environmental oestrogen; male reproductive tract; oestrogen receptors;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
51
Recensione:
Indirizzi per estratti:
Indirizzo: Sharpe, RM MRC, Human Reprod Sci Unit, Ctr Reprod Biol, 37 Chalmers St, Edinburgh EH39ET, Midlothian, Scotland MRC 37 Chalmers St Edinburgh Midlothian Scotland EH3 9ET otland
Citazione:
K. Williams et al., "Neonatal exposure to potent and environmental oestrogens and abnormalitiesof the male reproductive system in the rat: evidence for importance of theandrogen-oestrogen balance and assessment of the relevance to man", HUM REP UPD, 7(3), 2001, pp. 236-247

Abstract

The effects on reproductive tract development in male rats, of neonatal exposure to potent (reference) oestrogens, diethylstilboestrol (DES) and ethinyl oestradiol (EE), with those of two environmental oestrogens, octylphenol and bisphenol A were systematically compared, Other treatments, such as administration of a gonadotrophin-releasing hormone antagonist (GnRHa) or the anti-oestrogen tamoxifen or the anti-androgen flutamide, were used to aidinterpretation of the pathways involved. All treatments were administered in the neonatal period before onset of puberty. The cellular sites of expression of androgen receptors (AR) and of oestrogen receptor-alpha (ER alpha)and ER beta were:also established throughout development of the reproductive system, The main findings were as follows: (i) all cell types that express AR also express one or both ERs at all stages of development; (ii) Sertoli cell expression of ERP occurs considerably earlier in development than does expression of AR; (iii) most germ cells, including fetal gonocytes,express ERP but not AR; (iv) treatment with high, but not low, doses of potent oestrogens such as DES and EE, induces widespread structural and cellular abnormalities of the testis and reproductive tract before puberty; (v) the latter changes are associated with loss of immunoexpression of AR in all affected tissues and a reduction in Leydig cell volume per testis; (vi) none of the effects in (iv) and (v) can be duplicated by treating with high-dose octylphenol or bisphenol A; (vi) none of the reproductive tract changes in (iv) and (v) can be induced by simply suppressing androgen production (GnRHa treatment) or action (flutamide treatment); and (vii) the adverse changesinduced by high-dose DES (iv and v) can be largely prevented by co-administration of testosterone. Thus, it is suggested that many of the adverse changes to the testis and reproductive tract induced by exposure to oestrogensresult from a combination of high oestrogen and low androgen action. High oestrogen action or low androgen action on their-own are unable to induce the same changes.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 17/01/21 alle ore 08:13:56