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Titolo:
DCX in PC12 cells: CREB-mediated transcription and neurite outgrowth
Autore:
Shmueli, O; Gdalyahu, A; Sorokina, K; Nevo, E; Avivi, A; Reiner, O;
Indirizzi:
Weizmann Inst Sci, Dept Mol Genet, IL-76100 Rehovot, Israel Weizmann Inst Sci Rehovot Israel IL-76100 enet, IL-76100 Rehovot, Israel Univ Haifa, Inst Evolut, IL-31999 Haifa, Israel Univ Haifa Haifa Israel IL-31999 fa, Inst Evolut, IL-31999 Haifa, Israel
Titolo Testata:
HUMAN MOLECULAR GENETICS
fascicolo: 10, volume: 10, anno: 2001,
pagine: 1061 - 1070
SICI:
0964-6906(20010501)10:10<1061:DIPCCT>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
NERVE GROWTH-FACTOR; SUBCORTICAL LAMINAR HETEROTOPIA; MICROTUBULE-ASSOCIATED PROTEIN; CYCLIC-AMP; LISSENCEPHALY SYNDROME; NEURONAL MIGRATION; GENE-EXPRESSION; DOUBLECORTIN; PHOSPHORYLATION; APOPTOSIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
60
Recensione:
Indirizzi per estratti:
Indirizzo: Reiner, O Weizmann Inst Sci, Dept Mol Genet, IL-76100 Rehovot, Israel Weizmann Inst Sci Rehovot Israel IL-76100 6100 Rehovot, Israel
Citazione:
O. Shmueli et al., "DCX in PC12 cells: CREB-mediated transcription and neurite outgrowth", HUM MOL GEN, 10(10), 2001, pp. 1061-1070

Abstract

Mutations in doublecortin (DCX) result in X-linked lissencephaly in males. To explore the role of DCX in differentiation and signal transduction we overexpressed DCX in PC12 cells. Our results indicate that DCX stabilizes microtubules and inhibits neurite outgrowth in nerve growth factor-induced differentiation. However, neurite length is increased when differentiation isinduced by epidermal growth factor and forskolin or by dibutyryl-cAMP, Furthermore, CREB-mediated transcription is downregulated, supporting the notion that cytoskeletal regulatory proteins can affect the transcriptional state of a cell. Using different constructs and mutations we reach the conclusion that microtubule stabilization is a key factor, but not the only one, in controlling neurite extension. Overexpression of a mutation found in a lissencephaly patient (S47R), completely blocks neurite outgrowth. We proposethat these functions are important during normal and abnormal brain development.

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Documento generato il 01/12/20 alle ore 22:51:22