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Titolo:
Pathology of lymphoma progression
Autore:
Muller-Hermelink, HK; Zettl, A; Pfeifer, W; Ott, G;
Indirizzi:
Univ Wurzburg, Inst Pathol, D-97080 Wurzburg, Germany Univ Wurzburg Wurzburg Germany D-97080 Pathol, D-97080 Wurzburg, Germany
Titolo Testata:
HISTOPATHOLOGY
fascicolo: 4, volume: 38, anno: 2001,
pagine: 285 - 306
SICI:
0309-0167(200104)38:4<285:POLP>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHRONIC LYMPHOCYTIC-LEUKEMIA; NON-HODGKINS-LYMPHOMA; B-CELL LYMPHOMA; EPSTEIN-BARR-VIRUS; FOLLICLE CENTER LYMPHOMA; HIGH-GRADE TRANSFORMATION; MARGINAL-ZONE LYMPHOMA; COMMON CLONAL ORIGIN; C-MYC ONCOGENE; COMPOSITE LYMPHOMA;
Keywords:
lymphoma; B-cell lymphoma; T-cell lymphoma; progression; transformation;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
157
Recensione:
Indirizzi per estratti:
Indirizzo: Muller-Hermelink, HK Univ Wurzburg, Inst Pathol, Josef Schneider Str 2, D-97080 Wurzburg, Germany Univ Wurzburg Josef Schneider Str 2 Wurzburg Germany D-97080
Citazione:
H.K. Muller-Hermelink et al., "Pathology of lymphoma progression", HISTOPATHOL, 38(4), 2001, pp. 285-306

Abstract

Reflecting the stepwise process of oncogenesis, lymphomas may cumulativelydevelop a more aggressive phenotype during the course of disease, a process referred to as lymphoma progression, Although morphological, clinical andbiological aspects of lymphoma progression do not always overlap, changes in lymphoma morphology frequently indicate alterations in the clinical and biological behaviour of the disease. Indolent and aggressive lymphomas in disease progression can either be clonally related or represent clonally unrelated neoplasms. We propose to use the term 'lymphoma progression' in a biological sense denoting only clonal development of and within a lymphoma entity. The term 'composite lymphoma' should be used as a merely descriptive morphological designation for different lymphoma entities in one individualirrespective of clonal relationship. Many types of aggressive B-cell non-Hodgkin's lymphomas and Hodgkin's lymphomas are reported to secondarily develop in lymphoma progression. Genetic changes associated with lymphoma progression frequently abrogate the differentiating effects of alterations occurring in indolent lymphomas, leading to increased cell proliferation. Withindifferent lymphoma entities, high-risk disease variants mimicking lymphomaprogression exist.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/09/20 alle ore 00:03:21