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Titolo:
Co-existence of tyrosine hydroxylase and calcitonin gene-related peptide in cochlear spiral modiolar artery of guinea pigs
Autore:
Qiu, JH; Steyger, PS; Trune, DR; Nuttall, AL;
Indirizzi:
Oregon Hlth Sci Univ, Dept Otolaryngol Head & Neck Surg, Oregon Hearing Res Ctr, Portland, OR 97201 USA Oregon Hlth Sci Univ Portland OR USA 97201 es Ctr, Portland, OR 97201 USA Fourth Mil Med Univ, Xijing Hosp, Xian 710032, Peoples R China Fourth Mil Med Univ Xian Peoples R China 710032 710032, Peoples R China Univ Michigan, Kresge Hearing Res Inst, Ann Arbor, MI 48109 USA Univ Michigan Ann Arbor MI USA 48109 ng Res Inst, Ann Arbor, MI 48109 USA
Titolo Testata:
HEARING RESEARCH
fascicolo: 1-2, volume: 155, anno: 2001,
pagine: 152 - 160
SICI:
0378-5955(200105)155:1-2<152:COTHAC>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
SUPERIOR CERVICAL-GANGLION; BLOOD-FLOW; TRIGEMINAL GANGLION; IN-VITRO; RAT; INNERVATION; VASOCONSTRICTION; VASODILATOR; CELLS; ELECTROPHYSIOLOGY;
Keywords:
spiral modiolar artery; tyrosine hydroxylase; calcitonin gene-related peptide; immunofluorescence; cochlea;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: Nuttall, AL Oregon Hlth Sci Univ, Dept Otolaryngol Head & Neck Surg, Oregon Hearing Res Ctr, 3181 SW Sam Jackson Pk Rd, Portland, OR 97201 USA OregonHlth Sci Univ 3181 SW Sam Jackson Pk Rd Portland OR USA 97201
Citazione:
J.H. Qiu et al., "Co-existence of tyrosine hydroxylase and calcitonin gene-related peptide in cochlear spiral modiolar artery of guinea pigs", HEARING RES, 155(1-2), 2001, pp. 152-160

Abstract

The distribution of tyrosine hydroxylase (TH) and calcitonin gene-related peptide (CGRP) on the cochlear spiral modiolar artery (SMA) was investigated in the guinea pig. The SMA was dissected from the modiolus so that the entire length of the vessel and many of its branches could be observed. Immunohistochemical labeling and double immunofluorescence were employed to localize each compound and to determine whether the TH and CGRP co-exist in neurons of the SMA. Microscopic examination of whole vessel preparations revealed numerous TH- and CGRP-positive neural networks innervating the SMA and its branches. The labeled neurons showed distinct arborization, varicosities and overlap, and were of different diameters. Confocal immunoflorescence microscopy of double-labeled TH and CGRP neurons showed that a number of the TH- and CGRP-positive neurons were colabeled. Thus, TH and CGRP partiallyco-exist within the neuronal innervation of SMA. These findings support;I hypothesis that specific neuropeptide and adrenergic neurons regulate cochlear blood now. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 10:06:27