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Titolo:
Sensitivity of unanesthetized chinchilla auditory system to noise burst onset, and the effects of carboplatin
Autore:
Phillips, DP; Hall, SE; Guo, Y; Burkard, R;
Indirizzi:
Dalhousie Univ, Dept Psychol, Hearing Res Lab, Halifax, NS B3H 4J1, CanadaDalhousie Univ Halifax NS Canada B3H 4J1 Lab, Halifax, NS B3H 4J1, Canada SUNY Buffalo, Ctr Hearing & Deafness, Buffalo, NY 14214 USA SUNY Buffalo Buffalo NY USA 14214 aring & Deafness, Buffalo, NY 14214 USA
Titolo Testata:
HEARING RESEARCH
fascicolo: 1-2, volume: 155, anno: 2001,
pagine: 133 - 142
SICI:
0378-5955(200105)155:1-2<133:SOUCAS>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
HAIR CELL LOSS; EVOKED-RESPONSE; RISE-TIME; CORTEX NEURONS; LEVEL; INNER; REPRESENTATION; OTOTOXICITY; AMPLITUDE; MASKING;
Keywords:
evoked response; auditory nerve; inferior colliculus; noise onset; carboplatin;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Phillips, DP Dalhousie Univ, Dept Psychol, Hearing Res Lab, Halifax, NS B3H 4J1, Canada Dalhousie Univ Halifax NS Canada B3H 4J1 NS B3H 4J1, Canada
Citazione:
D.P. Phillips et al., "Sensitivity of unanesthetized chinchilla auditory system to noise burst onset, and the effects of carboplatin", HEARING RES, 155(1-2), 2001, pp. 133-142

Abstract

The gross near-field responses of the auditory nerve and inferior colliculus to noise burst stimuli were recorded through intracranially implanted electrodes in six unanesthetized chinchillas. Responses were studied as a function of stimulus plateau amplitude and rise time, both before and after a systemic dose of 75 mg/kg of carbaplatin. Both recording sites showed sensitivity to stimulus level and rise time. Increases in stimulus level and decreases in stimulus rise time each produced increases in the response magnitude, and decreases in response latency. When the stimuli were re-specified as rate of pressure change at sound onset (Pa/s), the amplitude and latencyof responses at each site were found to be a direct function of rate of sound pressure change. These data provide the first confirmation in unanesthetized animals of previous single unit observations: in barbiturate-anesthetized cats. Carboplatin treatment resulted in a 20-80% loss of inner hair cells, a modest threshold elevation, and a 50 75'%, reduction in peak response amplitudes. The general patterns of sensitivity to stimulus level and rise time were not markedly affected by carboplatin, nor was the fashion in which response parameters (amplitude and latency) were ruled by rate of pressure change at sound onset. (C) 2001 Elsevier Science B.V. All rights reserved.

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Documento generato il 29/03/20 alle ore 01:07:46