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Titolo:
Susceptibility to noise exposure during postnatal development in rats
Autore:
Rybalko, N; Syka, J;
Indirizzi:
Acad Sci Czech Republ, Inst Expt Med, Prague 14220 4, Czech Republic Acad Sci Czech Republ Prague Czech Republic 14220 4 20 4, Czech Republic
Titolo Testata:
HEARING RESEARCH
fascicolo: 1-2, volume: 155, anno: 2001,
pagine: 32 - 40
SICI:
0378-5955(200105)155:1-2<32:STNEDP>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
AUDITORY EVOKED-RESPONSES; AWAKE GUINEA-PIGS; INFERIOR COLLICULUS; ACOUSTIC TRAUMA; AUDIOGENIC-SEIZURE; OTOTOXICITY; STEREOCILIA; ENHANCEMENT; ENZYMES; HEARING;
Keywords:
noise exposure; young rat; evoked response; threshold shift; enhancement;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
49
Recensione:
Indirizzi per estratti:
Indirizzo: Rybalko, N Acad Sci Czech Republ, Inst Expt Med, Videnska 1083, Prague 14220 4, CzechRepublic Acad Sci Czech Republ Videnska 1083 Prague Czech Republic 14220 4
Citazione:
N. Rybalko e J. Syka, "Susceptibility to noise exposure during postnatal development in rats", HEARING RES, 155(1-2), 2001, pp. 32-40

Abstract

Susceptibility to noise-induced hearing loss was studied during maturationin 70 female pigmented rats (strain Long Evans). Young rats, 3, 4, 5 and 6-7 weeks old, were exposed for 1 h to a broad-band noise with an intensity of 120 dB SPL. The thresholds and amplitudes of middle latency responses (MLR) recorded from electrodes implanted on the surface of the auditory cortex were analyzed before and after noise exposure. The results were compared with data from our previous study, in which the effects of broad-band noiseexposure on MLR were investigated in adult rats [Syka, J. and Rybalko. N. (2000) Hear. Res. 139. 59-68]. The hearing thresholds of 3-7 week old rats before noise exposure M were within the normal adult range. Noise exposure in young rats produced an adult-like pattern with an elevation of hearing thresholds. One two weeks post-exposure a recovery of MLR thresholds was observed, though full recovery only occurred in the low frequency range. Recovery of hearing thresholds in the high. frequency range depended on the age of the animal at the time of exposure. In all animals aged less that 6-7 weeks. exposure resulted in a permanent threshold shift in the range of 4-32 kHz. The mean values of permanent threshold shifts :It 16 kHz (the frequency of maximal hearing loss) were 53.0 +/- 4.5, 47.6 +/- 9.6, 37.5 +/- 7.5 and 27 +/- 10 dB for rats exposed at 3, 4, 5 and 6-7 weeks of age, respectively. Similar to adult rats, young rats exposed to noise exhibited an enhancement of MLR amplitudes. This amplitude enhancement was more pronounced in the high frequency range. In several rats exposed at 35 weeks of age. the recovery period to normal amplitudes was substantially prolonged and lasted 4-8 weeks in comparison with 1 3 weeks in adult rats. These results demonstrate a greater susceptibility to noise exposure in rats during the first 5 postnatal weeks. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 09:34:00