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Titolo:
Analytic power calculation for QTL linkage analysis of small pedigrees
Autore:
Rijsdijk, FV; Hewitt, JK; Sham, PC;
Indirizzi:
Inst Psychiat, Social Genet & Dev Psychiat Res Ctr, London SE5 8AF, England Inst Psychiat London England SE5 8AF at Res Ctr, London SE5 8AF, England Univ Colorado, Inst Behav Genet, Boulder, CO 80309 USA Univ Colorado Boulder CO USA 80309 nst Behav Genet, Boulder, CO 80309 USA
Titolo Testata:
EUROPEAN JOURNAL OF HUMAN GENETICS
fascicolo: 5, volume: 9, anno: 2001,
pagine: 335 - 340
SICI:
1018-4813(200105)9:5<335:APCFQL>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
SIB-PAIR ANALYSIS; QUANTITATIVE TRAITS; VARIANCE-COMPONENTS; ASSOCIATION; SAMPLES; DETECT;
Keywords:
variance components; QTL linkage; power; general pedigrees;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
14
Recensione:
Indirizzi per estratti:
Indirizzo: Rijsdijk, FV Inst Psychiat, Social Genet & Dev Psychiat Res Ctr, 111 Denmark Hill, London SE5 8AF, England Inst Psychiat 111 Denmark Hill London England SE5 8AF ngland
Citazione:
F.V. Rijsdijk et al., "Analytic power calculation for QTL linkage analysis of small pedigrees", EUR J HUM G, 9(5), 2001, pp. 335-340

Abstract

Power calculation for QTL linkage analysis can be performed via simple algebraic formulas for small pedigrees, but requires intensive computation forlarge pedigrees, in order to evaluate the expectation of the test statistic over all possible inheritance vectors at the test position. In this report, we show that the noncentrality parameter for an arbitrary pedigree can be approximated by the sum of the variances of the correlations between all pairs of relatives, each variance being weighted by a factor that is determined by the mean correlation of the pair. We show that this approximation is sufficiently accurate for practical purposes in small to moderately largepedigrees, and that large sibships ate more efficient than other family structures under a range of genetic models.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 13:29:10