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Titolo:
Bullous pemphigoid in a leg affected with hemiparesia: a possible relationof neurological diseases with bullous pemphigoid?
Autore:
Foureur, N; Descamps, V; Lebrun-Vignes, B; Picard-Dahan, C; Grossin, M; Belaich, S; Crickx, B;
Indirizzi:
Hop Bichat Claude Bernard, Dept Dermatol, F-75018 Paris, France Hop BichatClaude Bernard Paris France F-75018 ol, F-75018 Paris, France Hop Bichat Claude Bernard, Dept Anatomopathol, F-75018 Paris, France Hop Bichat Claude Bernard Paris France F-75018 ol, F-75018 Paris, France
Titolo Testata:
EUROPEAN JOURNAL OF DERMATOLOGY
fascicolo: 3, volume: 11, anno: 2001,
pagine: 230 - 233
SICI:
1167-1122(200105/06)11:3<230:BPIALA>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
HEMIPLEGIC PATIENT; MULTIPLE-SCLEROSIS; DYSTONIN; ORGANIZATION; DEGENERATION; CLONING; NEURONS; BPAG1-N; GENE; MICE;
Keywords:
bullous pemphigoid; bullous pemphigoid antigen 1; dystonin; neurological disorder;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Descamps, V Hop Bichat Claude Bernard, Dept Dermatol, 46 Rue Henri Huchard, F-75018 Paris, France Hop Bichat Claude Bernard 46 Rue Henri Huchard Paris France F-75018
Citazione:
N. Foureur et al., "Bullous pemphigoid in a leg affected with hemiparesia: a possible relationof neurological diseases with bullous pemphigoid?", EUR J DERM, 11(3), 2001, pp. 230-233

Abstract

We report a typical case of bullous pemphigoid (BP) associated with a neurological disorder and study a possible link between neurological disorders and BP. An 84-year-old hemiplegic woman presented with unilateral BP on the hemiparetic side. BP was confirmed by histological and immunofluorescence data. The medical records of the previous 46 consecutive patients with BP were retrospectively analyzed (average age: 79; median age: 85), Thirty of the 46patients with BP had neurological disorders. These disorders included dementia, epilepsy, multiple sclerosis, cerebral stroke, Parkinson's disease, gonadotropic adenoma, trembling, dyskinesia, lumbar spinal stenosis, In a control group of the 46 consecutive oldest patients (older than 71; average age: 82,5; median age: 80) with another skin disease referred during the previous two-year-period to our one-day-unit only, 13 patients had a neurological disorder. This study demonstrates that there is a high prevalence of neurological disorders in patients with BP (p = 0.0004), A prospective case control study with neurological examination and psychometrical evaluation iswarranted to confirm these data. We speculate that neuroautoimmunity associated with the aging process or neurological disorders may be involved in pemphigoid development via an autoimmune response against dystonin which shares homology with bullous pemphigoid antigen 1. Bullous pem phigoid could be considered to be a marker of neurological disorder.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 01:36:53