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Titolo:
Efflux transport systems for drugs at the blood-brain barrier and blood-cerebrospinal fluid barrier (Part 1)
Autore:
Kusuhara, H; Sugiyama, Y;
Indirizzi:
Univ Tokyo, Fac Pharmaceut Sci, Dept Biopharmaceut, Tokyo 113, Japan Univ Tokyo Tokyo Japan 113 eut Sci, Dept Biopharmaceut, Tokyo 113, Japan
Titolo Testata:
DRUG DISCOVERY TODAY
fascicolo: 3, volume: 6, anno: 2001,
pagine: 150 - 156
SICI:
1359-6446(200102)6:3<150:ETSFDA>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
RESISTANCE-ASSOCIATED PROTEIN; CHOROID-PLEXUS EPITHELIUM; ORGANIC ANION TRANSPORTER; ENDOTHELIAL-CELL LINE; IN-VIVO EVIDENCE; P-GLYCOPROTEIN; RAT-BRAIN; CYCLOSPORINE-A; LOCALIZATION; SUBSTRATE;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
56
Recensione:
Indirizzi per estratti:
Indirizzo: Kusuhara, H Univ Tokyo, Fac Pharmaceut Sci, Dept Biopharmaceut, 7-3-1 Hongo, Tokyo 113, Japan Univ Tokyo 7-3-1 Hongo Tokyo Japan 113 ongo, Tokyo 113, Japan
Citazione:
H. Kusuhara e Y. Sugiyama, "Efflux transport systems for drugs at the blood-brain barrier and blood-cerebrospinal fluid barrier (Part 1)", DRUG DISC T, 6(3), 2001, pp. 150-156

Abstract

Penetration through the blood-brain barrier (BBB) and blood-cerebrospinal fluid barrier (BCSF B) is necessary if a drug is to achieve the required concentration for a desired pharmacological effect. Efflux transport systems at the BBB and BCSFB provide a protective barrier function by removing drugs from the brain or cerebrospinal fluid and transferring them to the systemic circulation, respectively; several transporters at the BBB and BCSFB have been identified. Efflux transport should be taken into consideration during drug development to improve brain penetration and to avoid drug-drug interactions involving these transporters and subsequent side effects.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/03/20 alle ore 23:34:25