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Titolo:
Nonresponse to first-line pharmacotherapy may predict relapse and recurrence of remitted geriatric depression
Autore:
Flint, AJ; Rifat, SL;
Indirizzi:
Toronto Gen Hosp, Geriatr Psychiat Program, Toronto, ON M5G 2C4, Canada Toronto Gen Hosp Toronto ON Canada M5G 2C4 m, Toronto, ON M5G 2C4, Canada Univ Toronto, Dept Psychiat, Toronto, ON, Canada Univ Toronto Toronto ON Canada ronto, Dept Psychiat, Toronto, ON, Canada Univ Toronto, Dept Prevent Med & Biostat, Toronto, ON, Canada Univ Toronto Toronto ON Canada revent Med & Biostat, Toronto, ON, Canada
Titolo Testata:
DEPRESSION AND ANXIETY
fascicolo: 3, volume: 13, anno: 2001,
pagine: 125 - 131
SICI:
1091-4269(2001)13:3<125:NTFPMP>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
MONOAMINE-OXIDASE INHIBITORS; LATE-LIFE DEPRESSION; MAJOR DEPRESSION; ELDERLY PATIENTS; ANTIDEPRESSANT TREATMENT; MAINTENANCE TREATMENT; ANXIOUS DEPRESSION; NORTRIPTYLINE; CONTINUATION; PHENELZINE;
Keywords:
geriatric depression; treatment resistance; relapse; recurrence; antidepressant medication;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Clinical Medicine
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Flint, AJ Toronto Gen Hosp, Geriatr Psychiat Program, 8 Eaton N,Room 238,200 Elizabeth St, Toronto, ON M5G 2C4, Canada Toronto Gen Hosp 8 Eaton N,Room 238,200 Elizabeth St Toronto ON Canada M5G 2C4
Citazione:
A.J. Flint e S.L. Rifat, "Nonresponse to first-line pharmacotherapy may predict relapse and recurrence of remitted geriatric depression", DEPRESS ANX, 13(3), 2001, pp. 125-131

Abstract

The authors examined whether nonresponse to first-line pharmacotherapy wasassociated with an increased probability of relapse or recurrence following remission of an episode of geriatric depression. The study group consisted of 74 elderly patients whose index episode of nonpsychotic unipolar majordepression had responded to antidepressant pharmacotherapy. lit 6 of thesepatients, the depressive episode had not responded to first-line pharmacotherapy (8 weeks of nortriptyline, including 2 weeks of adjuctive lithium) bat it had responded to second-line treatment (phenelzine with or without adjunctive lithium). The 74 patients were maintained on acute doses of the medications that had led to response and were followed for 2 years or until relapse or recurrence, whichever occurred first. The cumulative probability of relapse or recurrence was 67% for patients who responded to second-line treatment compared with 18% for patients who responded to first-line treatment (P=0.0003). As expected, mean time to response was significantly longerfor patients who responded to second-line treatment but this factor did not account for the difference in outcome between the two groups. These findings suggest that pharmacotherapy resistance may constitute a risk factor for relapse or recurrence of remitted geriatric depression, even when patients are maintained on the medication that they eventually respond to. (C) 2001 Wiley-Liss, Inc.

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Documento generato il 24/01/20 alle ore 15:25:53