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Titolo:
Imaging of dopaminergic transmission in neuropsychiatric disorders
Autore:
Verhoeff, NPLG;
Indirizzi:
Ctr Addict & Mental Hlth, PET Ctr, Toronto, ON M5T 1R8, Canada Ctr Addict & Mental Hlth Toronto ON Canada M5T 1R8 to, ON M5T 1R8, Canada Univ Toronto, Dept Psychiat, Toronto, ON, Canada Univ Toronto Toronto ON Canada ronto, Dept Psychiat, Toronto, ON, Canada Ctr Addict & Mental Hlth, Schizophrenia & Continuing Care Div, Toronto, ONM5T 1R8, Canada Ctr Addict & Mental Hlth Toronto ON Canada M5T 1R8 nto, ONM5T 1R8, Canada
Titolo Testata:
CURRENT OPINION IN PSYCHIATRY
fascicolo: 3, volume: 14, anno: 2001,
pagine: 227 - 239
SICI:
0951-7367(200105)14:3<227:IODTIN>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON-EMISSION-TOMOGRAPHY; ADVANCED PARKINSONS-DISEASE; I-123 BETA-CIT; STRIATAL DOPAMINE; IN-VIVO; C-11 RACLOPRIDE; HUNTINGTONS-DISEASE; FUNCTIONAL MRI; BASAL GANGLIA; OLIVOPONTOCEREBELLAR ATROPHY;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Citazioni:
124
Recensione:
Indirizzi per estratti:
Indirizzo: Verhoeff, NPLG Ctr Addict & Mental Hlth, PET Ctr, Clarke Site,250 Coll St,Toronto, ON M5T 1R8, Canada Ctr Addict & Mental Hlth Clarke Site,250 Coll St Toronto ON Canada M5T 1R8
Citazione:
N.P.L.G. Verhoeff, "Imaging of dopaminergic transmission in neuropsychiatric disorders", CUR OPIN P, 14(3), 2001, pp. 227-239

Abstract

The present review addresses recent advances in imaging dopaminergic neurotransmission in vivo. Radiotracer imaging with positron emission tomographyand single-photon emission computed tomography can be used to measure pre-, post- and intrasynaptic aspects of dopaminergic transmission. The presynaptic sites can be labelled with radiotracers for the dopamine transporter or the synthetic enzyme aromatic L-amino acid decarboxylase. The postsynaptic sites can be labelled with radiotracers for the dopamine D1 receptor or the dopamine D2 receptor. Estimates of synaptic endogenous dopamine release are made indirectly by measurements of the displacement of receptor tracersby dopamine. Agents are used that either release (e.g. amphetamine) or deplete (e.g. alpha -methyl-paratyrosine, an inhibitor of tyrosine hydroxylase) dopamine tissue stores. Functional magnetic resonance imaging and positron emission tomography can provide measures of the effect of changes in dopaminergic transmission on neuronal function, as indexed by a change in regional cerebral blood flow, oxygen utilization or glucose metabolism. Magneticresonance spectroscopy can provide measures of the effect of changes in dopaminergic transmission on the concentration of various neurochemical substances in cerebral tissue. Examples of recent applications of these imaging techniques in some neuropsychiatric diseases are provided. Curr Opin Psychiatry 14:227-239. (C) 2001 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 06:23:21