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Titolo:
Diversity in translational regulation
Autore:
Macdonald, P;
Indirizzi:
Univ Texas, Inst Mol & Cellular Biol, Sect Mol Cell & Dev Biol, Austin, TX78712 USA Univ Texas Austin TX USA 78712 t Mol Cell & Dev Biol, Austin, TX78712 USA
Titolo Testata:
CURRENT OPINION IN CELL BIOLOGY
fascicolo: 3, volume: 13, anno: 2001,
pagine: 326 - 331
SICI:
0955-0674(200106)13:3<326:DITR>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
OSKAR MESSENGER-RNA; XENOPUS OOCYTE MATURATION; LOCAL PROTEIN-SYNTHESIS; CYTOPLASMIC POLYADENYLATION; BINDING-PROTEIN; POLY(A) TAIL; POLY(A)-BINDING PROTEIN; CAENORHABDITIS-ELEGANS; DEPENDENT TRANSLATION; C-ELEGANS;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
53
Recensione:
Indirizzi per estratti:
Indirizzo: Macdonald, P Univ Texas, Inst Mol & Cellular Biol, Sect Mol Cell & Dev Biol, 2500 Speedway, Austin, TX 78712 USA Univ Texas 2500 Speedway Austin TX USA 78712 in, TX 78712 USA
Citazione:
P. Macdonald, "Diversity in translational regulation", CURR OP CEL, 13(3), 2001, pp. 326-331

Abstract

Translational control of individual mRNAs relies on cis-regulatory elements, which are often found in the 3' untranslated region. The best characterized of these regulate cytoplasmic polyadenylation, and much of this processcan now be defined in terms of molecular interactions, protein modifications and their consequences. Biochemical and genetic approaches have advancedthe understanding of the many instances of translational regulation that are crucial for body patterning in Drosophila. For example, in vitro translation systems have been used to study the regulatory mechanisms, and geneticinteractions have been instrumental in establishing a link between a regulatory factor and a component of the translational apparatus. Although most examples of control are thought to affect the initiation of translation, two classes of regulatory factors, one a protein and one a short non-coding RNA now appear to inhibit protein synthesis during elongation. Diversity seems to be a central feature of translational control, both in the mechanismsthemselves and in the situations where this form of regulation is used.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 02:24:39