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Titolo:
QTL analysis identifies multiple behavioral dimensions in ethological tests of anxiety in laboratory mice
Autore:
Turri, MG; Datta, SR; DeFries, J; Henderson, ND; Flint, J;
Indirizzi:
Wellcome Trust Ctr Human Genet, Oxford OX3 7BN, England Wellcome Trust CtrHuman Genet Oxford England OX3 7BN d OX3 7BN, England Univ Colorado, Inst Behav Genet, Boulder, CO 80309 USA Univ Colorado Boulder CO USA 80309 nst Behav Genet, Boulder, CO 80309 USA Oberlin Coll, Oberlin, OH 44074 USA Oberlin Coll Oberlin OH USA 44074Oberlin Coll, Oberlin, OH 44074 USA
Titolo Testata:
CURRENT BIOLOGY
fascicolo: 10, volume: 11, anno: 2001,
pagine: 725 - 734
SICI:
0960-9822(20010515)11:10<725:QAIMBD>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
QUANTITATIVE TRAIT LOCI; HALOPERIDOL-INDUCED CATALEPSY; RECOMBINANT INBRED MICE; ELEVATED PLUS-MAZE; ANIMAL-MODELS; ALCOHOL-WITHDRAWAL; HORMONE RECEPTOR-2; KNOCKOUT MICE; SENSITIVITY; EMOTIONALITY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
55
Recensione:
Indirizzi per estratti:
Indirizzo: Flint, J Wellcome Trust Ctr Human Genet, Oxford OX3 7BN, England Wellcome Trust Ctr Human Genet Oxford England OX3 7BN , England
Citazione:
M.G. Turri et al., "QTL analysis identifies multiple behavioral dimensions in ethological tests of anxiety in laboratory mice", CURR BIOL, 11(10), 2001, pp. 725-734

Abstract

Background: Ethological tests of anxiety-related behaviors, such as the open field arena and elevated plus maze, are often carried out on transgenic animals in the attempt to correlate gene function with a behavioral phenotype. However, the interpretation of such tests is problematic, as it is probable that different tests measure different aspects of behavior; indeed, anxiety may not be a unitary phenomenon. Here, we address these questions by asking whether behaviors in five ethological tests of anxiety are under theinfluence of a common set of genes. Results: Using over 1600 F2 intercross animals, we demonstrate that separate, but overlapping, genetic effects can be detected that influence different behavioral dimensions in the open field, elevated plus maze, square maze, light-dark box, and mirror chamber. We find quantitative trait loci (QTLs) on chromosomes 1, 4, and 15 that operate in four tests of anxiety but canbe differentiated by their action on behavior in threatening and nonthreatening environments and by whether habituation of the animals to an aversiveenvironment alters their influence. QTLs on chromosomes 7, 12, 14, 18, andX influenced a subset of behavioral measures. Conclusions: The chromosome 15 QTL acts primarily on avoidance behavior, the chromosome 1 QTL influences exploration, and the QTL on chromosome 4 influences activity. However, the effects of loci on other chromosomes are notso readily reconciled with our current understanding of the psychology of anxiety. Genetic effects on behaviors in these tests are more complex than expected and may not reflect an influence on anxiety.

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Documento generato il 27/01/20 alle ore 07:44:12