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Titolo:
Applications of magnetic resonance spectroscopy to chronic liver disease
Autore:
Taylor-Robinson, SD;
Indirizzi:
Imperial Coll Sch Med, Dept Med A, Div Med, London W12 1NY, England Imperial Coll Sch Med London England W12 1NY ed, London W12 1NY, England
Titolo Testata:
CLINICAL MEDICINE
fascicolo: 1, volume: 1, anno: 2001,
pagine: 54 - 60
SICI:
1470-2118(200101/02)1:1<54:AOMRST>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHRONIC HEPATIC-ENCEPHALOPATHY; PORTAL-SYSTEMIC ENCEPHALOPATHY; H-1 MR SPECTROSCOPY; IN-VIVO; HYPOTHERMIC REPERFUSION; NONINVASIVE ASSESSMENT; ELECTRON-MICROSCOPY; CEREBRAL PROTON; PIG-LIVER; P-31 MRS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: Taylor-Robinson, SD Imperial Coll Sch Med, Dept Med A, Div Med, Hammersmith Campus, London W121NY, England Imperial Coll Sch Med Hammersmith Campus London England W12 1NY
Citazione:
S.D. Taylor-Robinson, "Applications of magnetic resonance spectroscopy to chronic liver disease", CLIN MED, 1(1), 2001, pp. 54-60

Abstract

In vivo magnetic resonance spectroscopy (MRS) provides a non-invasive 'window' on biochemical processes within the body. The technique is currently aresearch tool, but new developments in whole-body magnetic resonance imaging (MRI) may provide a role for clinical MRS in obtaining functional information at the end of a standard MRI examination. Applications of hepatic andcerebral MRS to chronic liver disease and its associated complications arespecifically considered in this article. Changes in phosphorus-31 MRS withthe underlying functional severity of the cirrhotic liver are discussed. These reflect increased turnover of cell membranes as the liver attempts to regenerate. Patterns of spectral abnormality in the transplanted liver are described, and also the potential use of the technique to assess the viability of the stored donor liver in the time period between organ harvesting and implantation in the transplant recipient. Metabolite abnormalities in the brain are defined in hepatic encephalopathy and in patients infected withthe hepatitis C virus who have minimal hepatic inflammation. Future trendsare considered: for example, the use of MRS as a non-invasive tool to assess the effectiveness of liver-directed gene therapy.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/01/21 alle ore 03:33:48