Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Excretion of sweat and urine pyridinoline crosslinks in healthy controls and subjects with established metabolic bone disease
Autore:
Sarno, M; Sarno, L; Baylink, D; Drinkwater, B; Farley, S; Kleerekoper, M; Lang, R; Lappe, J; Licata, A; McClung, M; Miller, P; Nattrass, S; Recker, R; Schwartz, EN; Tucci, JR; Wolf, S; Powell, H; Tjersland, G; Warnick, GR;
Indirizzi:
Vis Biotechnol Consulting, Escondido, CA USA Vis Biotechnol Consulting Escondido CA USA Consulting, Escondido, CA USA Loma Linda Univ, Osteoporosis Ctr, Loma Linda, CA USA Loma Linda Univ Loma Linda CA USA , Osteoporosis Ctr, Loma Linda, CA USA Pacific Med Ctr, Seattle, WA USA Pacific Med Ctr Seattle WA USAPacific Med Ctr, Seattle, WA USA Wayne State Univ, Sch Med, Detroit, MI USA Wayne State Univ Detroit MI USA yne State Univ, Sch Med, Detroit, MI USA Creighton Univ, Osteoporosic Res Ctr, Omaha, NE 68178 USA Creighton Univ Omaha NE USA 68178 teoporosic Res Ctr, Omaha, NE 68178 USA Cleveland Clin Fdn, Cleveland, OH 44195 USA Cleveland Clin Fdn Cleveland OH USA 44195 in Fdn, Cleveland, OH 44195 USA Oregon Osteoporosis Ctr, Portland, OR USA Oregon Osteoporosis Ctr Portland OR USA teoporosis Ctr, Portland, OR USA Colorado Ctr Bone Res, Lakewood, CO USA Colorado Ctr Bone Res Lakewood COUSA ado Ctr Bone Res, Lakewood, CO USA Fdn Osteoporosis Res & Educ, Oakland, CA USA Fdn Osteoporosis Res & Educ Oakland CA USA s Res & Educ, Oakland, CA USA Roger Williams Med Ctr, Providence, RI USA Roger Williams Med Ctr Providence RI USA ams Med Ctr, Providence, RI USA Virginia Mason Med Ctr, Seattle, WA 98101 USA Virginia Mason Med Ctr Seattle WA USA 98101 ed Ctr, Seattle, WA 98101 USA Pacific Biometr Inc, Seattle, WA USA Pacific Biometr Inc Seattle WA USAPacific Biometr Inc, Seattle, WA USA Univ Washington, Seattle, WA 98195 USA Univ Washington Seattle WA USA 98195 iv Washington, Seattle, WA 98195 USA Pacific Biometr Res Fdn, Issaquah, WA USA Pacific Biometr Res Fdn Issaquah WA USA iometr Res Fdn, Issaquah, WA USA Pettis VAMC, Loma Linda, CA USA Pettis VAMC Loma Linda CA USAPettis VAMC, Loma Linda, CA USA
Titolo Testata:
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
fascicolo: 3, volume: 39, anno: 2001,
pagine: 223 - 228
SICI:
1434-6621(200103)39:3<223:EOSAUP>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
BIOCHEMICAL MARKERS; LINKS; COLLAGEN; BISPHOSPHONATE; OSTEOPOROSIS; RESORPTION; TURNOVER;
Keywords:
enzyme immunoassay; bone markers; pyridinoline crosslinks;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Sarno, M 306-N W El Norte Pkwy,PMB 311, Escondido, CA 92026 USA 306-N W El Norte Pkwy,PMB 311 Escondido CA USA 92026 A 92026 USA
Citazione:
M. Sarno et al., "Excretion of sweat and urine pyridinoline crosslinks in healthy controls and subjects with established metabolic bone disease", CLIN CH L M, 39(3), 2001, pp. 223-228

Abstract

Convenient techniques for measuring rates of bone turnover have been developed in recent years with the advent of biochemical markers of bone metabolism. One recent of these techniques is a collection method and quantitativeenzyme immunoassay for free pyridinoline crosslinks in human sweat. The concentrations of pyridinoline crosslinks in 5-day sweat collections and first morning void and 24-hour urine collections from healthy subjects and subjects with established metabolic bone disorders were determined. T-scores were higher in the sweat system than in the urine system by up to 10-fold in postmenopausal subjects, women with hyperparathyroidism, and subjects with postmenopausal osteoporosis. For subjects with postmenopausal osteoporosis,receiver-operating characteristic curve analysis yielded areas under the curve of 0.699, 0.629, and 0.520 for sweat pyridinoline, first morning void urine pyridinoline, and 24 hour urine pyridinoline respectively. The areas under the curve of the sweat and first morning void urine measurements weresignificantly greater (p <0.05) than the 24-hour pyridinoline measurements. Healthy postmenopausal subjects and subjects with postmenopausal osteoporosis were monitored before and during estrogen replacement therapy or alendronate therapy. Sweat pyridinoline values declined by 49.0 +/- 12.4% and 19.4 +/- 19.9% for estrogen and alendronate subjects respectively. We conclude that this non-invasive technique is a sensitive and specific measure of bone resorption and is appropriate as an adjunct to techniques such as bone density and may also be useful in monitoring of response to anti-resorptivetherapies.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 10:35:18