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Titolo:
Expression of MUC1 mucins in the subserosal layer correlates with postsurgical prognosis of pathological tumor stage 2 carcinoma of the gallbladder
Autore:
Kawamoto, T; Shoda, J; Irimura, T; Miyahara, N; Furukawa, M; Ueda, T; Asano, T; Kano, M; Koike, N; Fukao, K; Tanaka, N; Todoroki, T;
Indirizzi:
Univ Tsukuba, Inst Clin Med, Dept Gastroenterol, Tsukuba, Ibaraki 3058575,Japan Univ Tsukuba Tsukuba Ibaraki Japan 3058575 Tsukuba, Ibaraki 3058575,Japan Univ Tsukuba, Inst Clin Med, Dept Gastrointestinal Surg, Tsukuba, Ibaraki 3058575, Japan Univ Tsukuba Tsukuba Ibaraki Japan 3058575 sukuba, Ibaraki 3058575, Japan Univ Tokyo, Fac Pharmaceut Sci, Dept Canc Biol & Mol Immunol, Tokyo 1130033, Japan Univ Tokyo Tokyo Japan 1130033 Biol & Mol Immunol, Tokyo 1130033, Japan Nagasaki Cent Natl Hosp, Dept Surg 2, Nagasaki 8560835, Japan Nagasaki Cent Natl Hosp Nagasaki Japan 8560835 , Nagasaki 8560835, Japan Mitsubishi Kagaku Bio Clin Labs Inc, Pharmaceut Res Dept, Tokyo 1748555, Japan Mitsubishi Kagaku Bio Clin Labs Inc Tokyo Japan 1748555 o 1748555, Japan
Titolo Testata:
CLINICAL CANCER RESEARCH
fascicolo: 5, volume: 7, anno: 2001,
pagine: 1333 - 1342
SICI:
1078-0432(200105)7:5<1333:EOMMIT>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN COLORECTAL-CARCINOMA; CELL-ADHESION; SURGICAL-TREATMENT; RADICAL RESECTION; SOLUBLE FACTOR; CANCER; COLON; ANTIGEN; METASTASIS; SIALOMUCIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
46
Recensione:
Indirizzi per estratti:
Indirizzo: Shoda, J Univ Tsukuba, Inst Clin Med, Dept Gastroenterol, 1-1-1 Tennodai, Tsukuba, Ibaraki 3058575, Japan Univ Tsukuba 1-1-1 Tennodai Tsukuba IbarakiJapan 3058575 , Japan
Citazione:
T. Kawamoto et al., "Expression of MUC1 mucins in the subserosal layer correlates with postsurgical prognosis of pathological tumor stage 2 carcinoma of the gallbladder", CLIN CANC R, 7(5), 2001, pp. 1333-1342

Abstract

The overall outcome of pT(2) gallbladder carcinoma has not been favorable,Postsurgical recurrence at distant sites occurs in some cases, although the carcinoma was limited to the gallbladder wall. A high level expression ofMUC1 mucins with sialylated carbohydrates (sialylated MUC1 mucins) is correlated with poor survival in intrahepatic bile duct carcinoma. In the present study, immunohistochemistry was performed to determine the expression level of sialylated MUC1 mucins, detected by a monoclonal antibody, MY.1E12, in 31 cases of pT(2) gallbladder carcinoma on which curative resections hadbeen performed and to determine the correlation of the expression level ofMY.1E12-reactive-MUC1 mucin with mode of recurrence and postsurgical survival, Immunostainings of the MUC1 mucin were recognized in different types of noncancerous pathological epithelia of the gallbladder except for intestinal metaplasia and cancerous epithelia, Immunohistochemical localization was classified into apical, cytoplasmic, and stromal types based on the predominant cellular distribution of MY.1E12-reactive-MUC1 mucin, In 31 cases ofpT(2) carcinoma, the localization was apical type in 64%, cytoplasmic typein 71%, and stromal type in 48% of the cases at the deepest invading sitesin the subserosal layer. Distant recurrences, i,e,, peritoneal dissemination in 8 patients and liver metastasis in 3 patients, were seen in 8 (53%) of 15 cases of pT(2) carcinoma that had greater than or equal to 10% of the cancerous epithelia shelving stromal localization of the MUC1 mucin at the deepest invading sites and in 2 (12%) of 16 cases that had < 10% of those showing the stromal localization. The postsurgical survival outcome was significantly poorer in the former than in the latter (P = 0,044), In pT(2) gallbladder carcinoma, the presence of MY.1E12-reactive-MUC1 mucin in the stroma adjacent to the cancerous epithelia in the subserosal layer correlates with the aggressiveness of the disease, such as the tendency to form distantrecurrences. This phenotype may serve as a unique biological feature associated with the malignant behavior of pT(2) gallbladder carcinoma.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/07/20 alle ore 23:03:02