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Titolo:
Significant correlation between interleukin 10 expression and vascularization through angiopoietin/TIE2 networks in non-small cell lung cancer
Autore:
Hatanaka, H; Abe, Y; Naruke, M; Tokunaga, T; Oshika, Y; Kawakami, T; Osada, H; Nagata, J; Kamochi, J; Tsuchida, T; Kijima, H; Yamazaki, H; Inoue, H; Ueyama, Y; Nakamura, M;
Indirizzi:
Tokai Univ, Sch Med, Dept Pathol, Kanagawa 2591193, Japan Tokai Univ Kanagawa Japan 2591193 , Dept Pathol, Kanagawa 2591193, Japan
Titolo Testata:
CLINICAL CANCER RESEARCH
fascicolo: 5, volume: 7, anno: 2001,
pagine: 1287 - 1292
SICI:
1078-0432(200105)7:5<1287:SCBI1E>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
RECEPTOR TYROSINE KINASE; PULMONARY ADENOCARCINOMA; COLORECTAL-CANCER; POOR-PROGNOSIS; TIE2 RECEPTOR; ANGIOGENESIS; TUMOR; GENE; METASTASIS; MECHANISMS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Nakamura, M Tokai Univ, Sch Med, Dept Pathol, Kanagawa 2591193, Japan Tokai Univ Kanagawa Japan 2591193 l, Kanagawa 2591193, Japan
Citazione:
H. Hatanaka et al., "Significant correlation between interleukin 10 expression and vascularization through angiopoietin/TIE2 networks in non-small cell lung cancer", CLIN CANC R, 7(5), 2001, pp. 1287-1292

Abstract

The expression of interleukin 10 (IL-10) is correlated with clinical prognosis in non-small cell lung cancer [NSCLC (H. Hatanaka et at, Ann. Oncol., 11: 815-819, 2000)]. However, the effects of IL-10 expression on vascularization in NSCLC are not apparent. We examined the gene expression of Il-10/IL-10 receptor and various angiogenic/angioinhibitory factors in 95 NSCLC samples to determine the correlation between IL-10 production and vascularization. Vascular endothelial growth factor, angiopoietin [Ang (Ang-1 and Ang-2)], thrombospondin, brain-specific angiogenesis inhibitor 1, vascular endothelial growth factor receptors (KDR and flt-1), and Ang receptor (TIE2) gene expression were evaluated by reverse transcription-PCR. The cellular localization of these factors and vascularity in the cancer stroma were examined immunohistochemically. Seventy-eight (82.1%) and 93 (97.9%) of these 95 NSCLCs were positive for IL-10 and IL-10 receptor, respectively. Ang-1, Ang-2, and TIE2 gene expression was seen in 76 (97.4%), 73 (93.6%), and 78 (100%) of 78 IL-10-positive NSCLCs, respectively, and was significantly correlated with ILIO gene expression (P < 0.0088, <0.0008, and 0.0305, respectively; Fisher's exact method). The localizations of Ang-l, Ang-2, and TIE2 were confirmed within tumor cells immunohistochemically. Vascular number and measurement area were significantly higher in the IL-10-positive NSCLCs (33.500 +/- 9.299/mum(2) and 4.742 +/- 1.287%) as compared with IL-IO-negative NSCLCs (10.611 +/- 2.839/ mum(2) and 0.718 +/- 0.331%; Mann-Whitney U test,P = 0.0039). The IL-10 expression did not show any significant correlationwith the expression of other factors. These results suggested that tumor-produced IL-10 promotes stromal vascularization through expression of Ang-l,Ang-2, and TIE2.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/06/20 alle ore 01:13:40