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Titolo:
Correction of coronal suture synostosis using suture and dura mater allografts in rabbits with familial craniosynostosis
Autore:
Mooney, MP; Burrows, AM; Smith, TD; Losken, HW; Opperman, LA; Dechant, J; Kreithen, AM; Kapucu, R; Cooper, GM; Ogle, RC; Siegel, MI;
Indirizzi:
Univ Pittsburgh, Dept Oral Med & Pathol, Pittsburgh, PA 15261 USA Univ Pittsburgh Pittsburgh PA USA 15261 Pathol, Pittsburgh, PA 15261 USA Univ Pittsburgh, Dept Anthropol, Div Plast & Reconstruct Surg, Pittsburgh,PA 15260 USA Univ Pittsburgh Pittsburgh PA USA 15260 uct Surg, Pittsburgh,PA 15260 USA Univ Pittsburgh, Dept Orthodont, Pittsburgh, PA 15260 USA Univ PittsburghPittsburgh PA USA 15260 thodont, Pittsburgh, PA 15260 USA Univ Pittsburgh, Cleft Palate Craniofacial Ctr, Pittsburgh, PA USA Univ Pittsburgh Pittsburgh PA USA e Craniofacial Ctr, Pittsburgh, PA USA Slippery Rock Univ, Sch Phys Therapy, Slippery Rock, PA 16057 USA SlipperyRock Univ Slippery Rock PA USA 16057 Slippery Rock, PA 16057 USA Childrens Hosp, Pittsburgh, PA 15213 USA Childrens Hosp Pittsburgh PA USA15213 ens Hosp, Pittsburgh, PA 15213 USA Texas A&M Univ, Ctr Hlth Sci, Baylor Coll Dent, Dept Biomed Sci, Dallas, TX USA Texas A&M Univ Dallas TX USA Coll Dent, Dept Biomed Sci, Dallas, TX USA Univ Pittsburgh, Dept Anat & Histol, Pittsburgh, PA USA Univ Pittsburgh Pittsburgh PA USA Dept Anat & Histol, Pittsburgh, PA USA Univ Virginia, Dept Neurol Surg Cell Biol & Plast Surg, Charlottesville, VA USA Univ Virginia Charlottesville VA USA Plast Surg, Charlottesville, VA USA
Titolo Testata:
CLEFT PALATE-CRANIOFACIAL JOURNAL
fascicolo: 3, volume: 38, anno: 2001,
pagine: 206 - 225
SICI:
1055-6656(200105)38:3<206:COCSSU>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
INCREASED INTRACRANIAL-PRESSURE; GROWTH-FACTOR-I; TRANSFORMING GROWTH-FACTOR-BETA-1; CRANIAL SUTURES; CRANIOFACIAL SURGERY; OSSEOUS OBLITERATION; TISSUE INTERACTIONS; BIOLOGY; FUSION; VITRO;
Keywords:
allografts; animal model; cephalometrics; coronal suture; craniofacial growth; craniosynostosis; cytokines; dura mater; growth factors; histomorphometry; rabbits; transplantation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
107
Recensione:
Indirizzi per estratti:
Indirizzo: Mooney, MP Univ Pittsburgh, Dept Oral Med & Pathol, 619 Salk Hall, Pittsburgh, PA 15261 USA Univ Pittsburgh 619 Salk Hall Pittsburgh PA USA 15261 15261 USA
Citazione:
M.P. Mooney et al., "Correction of coronal suture synostosis using suture and dura mater allografts in rabbits with familial craniosynostosis", CLEF PAL-CR, 38(3), 2001, pp. 206-225

Abstract

Objective: Resynostosis following surgical correction of craniosynostosis is a common clinical correlate. Recent studies suggest that the dura mater is necessary to maintain suture patency. It has also been hypothesized thatdura mater from synostotic individuals may provide aberrant biochemical signals to the osteogenic fronts of the calvaria, which result in premature suture fusion and subsequent resynostosis following surgery. This study was designed to test this hypothesis by surgically manipulating the coronal suture and dura mater in rabbits with familial craniosynostosis to prevent postsurgical resynostosis. Design: Craniofacial growth and histomorphometric data were collected from129 rabbits: 72 normal controls end 57 rabbits with bilateral coronel suture synostosis (15 unoperated on controls; 13 surgical controls; 9 dura mater transplant only; 10 suture transplant only; and 10 suture end dura mater transplant). At 10 days of age, all rabbits had radiopaque amalgam markers placed on either side of the coronel, frontonasal, and anterior lambdoidal sutures. At 25 days of age, 42 synostosed rabbits had a 3 to 5-mm wide coronal suturectomy. Coronal sutures and/or underlying dura mater allografts were harvested from same-aged, wildtype, isohistogenic central rabbits and transplanted onto the dura mater of synostosed host rabbits. Serial radiographs were taken at 10, 25, 42, and 84 days of age, and the suturectomy sites were harvested at 84 days of age in 44 rabbits and serially sectioned for histomorphometric examination. Results: Results revealed that cranial vault growth was significantly (p <.05) improved following surgical release of the fused coronel suture compared with synostosed rabbits who were not operated on but was still significantly different (p < .05) from that of normal control rabbits. By 84 days of age, significant (p < .05) differences were noted in calvarial suture marker separation, cranial vault shape indices, and cranial base angles between rabbits with and without dura mater allografts, probably as a result of resynostosis of the suturectomy site or suture-only allografts. Qualitative histological examination revealed that at 84 days of age rabbits with suture and dura allografts had patent coronal sutures, suture-only allografts had fused coronal sutures with extensive endosteal hyperostosis, dura mater-only allografts had some new bone in the suturectomy site that resembled rudimentary osteogenic fronts, end suturectomy controls had extensive endosteal bone formation and resynostosis of the suturectomy site. Significantly (p< .05) more bone was found in the suturectomy sites of rabbits without dura mater allografts compared with rabbits with dura mater allografts. Conclusions: Results support the initial hypothesis that normal dura materallografts will maintain suture or suturectomy site patency end allow unrestricted craniofacial growth. However, it is still unclear whether the duramater from normal rabbits was providing biochemical signals to the transplanted sutures or suturectomy sites or simply acting as a barrier to preventabnormal biochemical signals from the dura mater of synostosed rabbits from reaching the calvaria. The clinical and therapeutic implications of theseprocedures are discussed.

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Documento generato il 10/07/20 alle ore 18:09:25