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Titolo:
L-arginine and S-nitrosoglutathione reduce embolization in humans
Autore:
Kaposzta, Z; Baskerville, PA; Madge, D; Fraser, S; Martin, JF; Markus, HS;
Indirizzi:
St George Hosp, Sch Med, London SW17 0RE, England St George Hosp London England SW17 0RE Sch Med, London SW17 0RE, England Univ London Kings Coll Hosp, Dept Vasc Surg, London, England Univ London Kings Coll Hosp London England t Vasc Surg, London, England Univ Coll London, London, England Univ Coll London London EnglandUniv Coll London, London, England
Titolo Testata:
CIRCULATION
fascicolo: 19, volume: 103, anno: 2001,
pagine: 2371 - 2375
SICI:
0009-7322(20010515)103:19<2371:LASREI>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
ORAL L-ARGININE; ENDOTHELIUM-DEPENDENT DILATION; INHIBITS PLATELET-AGGREGATION; CAROTID-ARTERY STENOSIS; NITRIC-OXIDE; TRANSCRANIAL DOPPLER; HYPERCHOLESTEROLEMIC HUMANS; MICROEMBOLUS DETECTION; NITROSO-GLUTATHIONE; ACTIVATION;
Keywords:
ultrasonics; drugs; platelets; inhibitors; carotid arteries;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Markus, HS St George Hosp, Sch Med, Cranmer Terrace, London SW17 0RE, England St George Hosp Cranmer Terrace London England SW17 0RE England
Citazione:
Z. Kaposzta et al., "L-arginine and S-nitrosoglutathione reduce embolization in humans", CIRCULATION, 103(19), 2001, pp. 2371-2375

Abstract

Background-L-Arginine reduces platelet aggregation and adhesion in ex vivostudies, but there is no evidence as yet that it has a therapeutic effect on clinical end points. Doppler ultrasound can detect cerebral emboli noninvasively. Such embolic signals are common after carotid endarterectomy, andtheir frequency predicts risk of stroke recurrence. We used this situationto determine the antiplatelet efficacy of L-arginine and S-nitrosoglutathione (GSNO), a physiological nitric oxide donor with possible platelet specificity. Methods and Results-Patients undergoing carotid endarterectomy were randomized in a double-blind manner between L-arginine (n = 14), GSNO (n = 14), or placebo (n = 14) administered intravenously for 90 minutes, starting 30 minutes after skin closure. All patients were pretreated with aspirin and given heparin during surgery. Transcranial Doppler recordings were made from the ipsilateral middle cerebral artery for 4 hours after surgery, beginning30 minutes after skin closure, and also at 6 and 24 hours. There were highly significant reductions in the number of Doppler embolic signals in the L-arginine and GSNO groups; first 4 hours, median (range) number of embolic signals, placebo 44.7 (6 to 778), L-arginine 9.5 (0 to 225), and GSNO 0.8 (0 to 8), both P <0,001 versus control values. The reduction in the signals persisted at the 24-hour recording. Conclusions-Intravenous L-arginine and GSNO attenuate Doppler embolic signals in humans. Modulation of the NO system with these agents may have applications in the treatment of thromboembolic disease. This study demonstratesthe potential application of ultrasonic embolic signal detection to examine the efficacy of new antiplatelet agents in relatively small numbers of patients.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 21:53:24