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Titolo:
Does the relation of blood pressure to coronary heart disease risk change with aging? The Framingham Heart Study
Autore:
Franklin, SS; Larson, MC; Khan, SA; Wong, ND; Leip, EP; Kannel, WB; Levy, D;
Indirizzi:
Univ Calif Irvine, Prevent Cardiol Program, Irvine, CA 92697 USA Univ Calif Irvine Irvine CA USA 92697 rdiol Program, Irvine, CA 92697 USA NHLBI, Framingham Heart Study, Framingham, MA USA NHLBI Framingham MA USA HLBI, Framingham Heart Study, Framingham, MA USA NHLBI, Bethesda, MD 20892 USA NHLBI Bethesda MD USA 20892NHLBI, Bethesda, MD 20892 USA Boston Univ, Sch Med, Dept Epidemiol & Biostat, Boston, MA 02118 USA Boston Univ Boston MA USA 02118 Epidemiol & Biostat, Boston, MA 02118 USA
Titolo Testata:
CIRCULATION
fascicolo: 9, volume: 103, anno: 2001,
pagine: 1245 - 1249
SICI:
0009-7322(20010306)103:9<1245:DTROBP>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
ISOLATED SYSTOLIC HYPERTENSION; CARDIOVASCULAR MORTALITY; PREDICTORS;
Keywords:
blood pressure; hypertension; pulse pressure; coronary disease;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Franklin, SS Univ Calif Irvine, UCI Heart Dis Prevent Program, C240 Med Sci, Irvine, CA92697 USA Univ Calif Irvine C240 Med Sci Irvine CA USA 92697 A92697 USA
Citazione:
S.S. Franklin et al., "Does the relation of blood pressure to coronary heart disease risk change with aging? The Framingham Heart Study", CIRCULATION, 103(9), 2001, pp. 1245-1249

Abstract

Background-We examined the relative importance of diastolic (DBP), systolic (SBP) and pulse pressure (PP) as predictors of coronary heart disease (CHD) risk in different age groups of Framingham Heart Study participants. Methods and Results-We studied 3060 men and 3479 women between 20 and 79 years of age who were free of CHD and were not on antihypertensive drug therapy at baseline. Cox regression adjusted for age, sex, and other risk factors was used to assess the relations of BP indexes to CHD risk over a 20-year follow-up. In the group <50 years of age, DBP was the strongest predictorof CHD risk (hazard ratio [HR] per 10 mm Hg increment, 1.34; 95% CI, 1.18 to 1.51) rather than SBP (HR, 1.14; 95% CI, 1.06 to 1.24) or PP (HR, 1.02; 95% CI, 0.89 to 1.17). In the group 50 to 59 years of age, risks were comparable for all 3 BP indexes. In the older age group, the strongest predictorof CHD risk was PP (HR, 1.24; 95% CI, 1.16 to 1.33). When both SEP and DBPwere considered jointly, the former was directly and the latter was inversely related to CHD risk in the oldest age group. Conclusions-With increasing age, there was a gradual shift from DBP to SEPand then to PP as predictors of CHD risk. In patients <50 years of age, DBP was the strongest predictor. Age 50 to 59 years was a transition period when all 3 BP indexes were comparable predictors, and from 60 years of age on, DBP was negatively related to CHD risk so that PP became superior to SEP.

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Documento generato il 20/01/20 alle ore 22:12:43