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Titolo:
Regional dendritic and spine variation in human cerebral cortex: a quantitative Golgi study
Autore:
Jacobs, B; Schall, M; Prather, M; Kapler, E; Driscoll, L; Baca, S; Jacobs, J; Ford, K; Wainwright, M; Treml, M;
Indirizzi:
Colorado Coll, Dept Psychol, Lab Quantitat Neuromorphol, Colorado Springs,CO 80903 USA Colorado Coll Colorado Springs CO USA 80903 Colorado Springs,CO 80903 USA Univ Calif Davis, Dept Neurosci, Davis, CA 95616 USA Univ Calif Davis Davis CA USA 95616 s, Dept Neurosci, Davis, CA 95616 USA UNIFOCUS, Carrolton, TX 75006 USA UNIFOCUS Carrolton TX USA 75006UNIFOCUS, Carrolton, TX 75006 USA Cornell Univ, Dept Psychol, Ithaca, NY 14853 USA Cornell Univ Ithaca NY USA 14853 Univ, Dept Psychol, Ithaca, NY 14853 USA Univ Calif San Diego, Grad Program Neurosci, La Jolla, CA 92093 USA Univ Calif San Diego La Jolla CA USA 92093 urosci, La Jolla, CA 92093 USA Univ Texas, Dept Neurobiol & Anat, Houston, TX 77030 USA Univ Texas Houston TX USA 77030 t Neurobiol & Anat, Houston, TX 77030 USA
Titolo Testata:
CEREBRAL CORTEX
fascicolo: 6, volume: 11, anno: 2001,
pagine: 558 - 571
SICI:
1047-3211(200106)11:6<558:RDASVI>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON EMISSION TOMOGRAPHY; III PYRAMIDAL NEURONS; MONKEY VISUAL-CORTEX; MACAQUE MONKEY; PREFRONTAL CORTEX; ORBITOFRONTAL CORTEX; RHESUS-MONKEY; HUMAN-BRAIN; LAYER-III; CYTOARCHITECTONIC DEFINITION;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
105
Recensione:
Indirizzi per estratti:
Indirizzo: Jacobs, B Colorado Coll, Dept Psychol, Lab Quantitat Neuromorphol, 14 E Cache La Poudre, Colorado Springs, CO 80903 USA Colorado Coll 14 E Cache La Poudre Colorado Springs CO USA 80903
Citazione:
B. Jacobs et al., "Regional dendritic and spine variation in human cerebral cortex: a quantitative Golgi study", CEREB CORT, 11(6), 2001, pp. 558-571

Abstract

The present study explored differences in dendritic/spine extent across several human cortical regions. Specifically, the basilar dendrites/spines ofsupragranular pyramidal cells were examined in eight Brodmann's areas (BA)arranged according to Benson's functional hierarchy: primary cortex (somatosensory, BA3-1-2; motor, BA4), unimodal cortex (Wernicke's area, BA22: Broca's area, BA44), heteromodal cortex (supplementary motor area, BA6 beta; angular gyrus, BA39) and supramodal cortex (superior frontopolar zone, BA10;inferior frontopolar zone, BA11), To capture more general aspects of regional variability, primary and unimodal areas were designated as low integrative regions: heteromodal and supramodal areas were designated as high integrative regions. Tissue was obtained from the left hemisphere of 10 neurologically normal individuals (M-ago = 30 +/- 17 years; five males, five females) and stained with a modified rapid Golgi technique. Ten neurons were sampled from each cortical region (n = 800) and evaluated according to total dendritic length, mean segment length, dendritic segment count, dendritic spine number and dendritic spine density. Despite considerable inter-individual variation, there were significant differences across the eight Brodmann'sareas and between the high and low integrative regions for all dendritic and spine measures. Dendritic systems in primary and unimodal regions were consistently less complex than in heteromodal and supramodal areas. The range within these rankings was substantial, with total dendritic length in BA10 being 31% greater than that in BA3-1-2, and dendritic spins number being 69% greater. These findings demonstrate that cortical regions involved in the early stages of processing (e.g. primary sensory areas) generally exhibit less complex dendritic/spine systems than those regions involved in the later stages of information processing (e.g, prefrontal cortex). This dendritic progression appears to reflect significant differences in the nature ofcortical processing, with spine-dense neurons at hierarchically higher association levels integrating a broader range of synaptic input than those atlower cortical levels.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 08:54:45