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Titolo:
Normal sexual dimorphism of the adult human brain assessed by in vivo magnetic resonance imaging
Autore:
Goldstein, JM; Seidman, LJ; Horton, NJ; Makris, N; Kennedy, DN; Caviness, VS; Faraone, SV; Tsuang, MT;
Indirizzi:
Harvard Univ, Sch Med, Dept Psychiat, Massachusetts Mental Hlth Ctr, Boston, MA 02115 USA Harvard Univ Boston MA USA 02115 ts Mental Hlth Ctr, Boston, MA 02115 USA Harvard Univ, Sch Med, Dept Psychiat, Brockton W Roxbury Vet Affairs Med Ctr, Boston, MA 02115 USA Harvard Univ Boston MA USA 02115 et Affairs Med Ctr, Boston, MA 02115 USA Boston Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, Boston, MA USA Boston Univ Boston MA USA Hlth, Dept Epidemiol & Biostat, Boston, MA USA Boston Univ, Sch Med, Boston, MA 02118 USA Boston Univ Boston MA USA 02118 oston Univ, Sch Med, Boston, MA 02118 USA Harvard Univ, Sch Med, Dept Neurol, Boston, MA 02129 USA Harvard Univ Boston MA USA 02129 h Med, Dept Neurol, Boston, MA 02129 USA Harvard Univ, Sch Med, Dept Radiol Sci, Ctr Morphometr Anal,Massachusetts Gen Hosp, Boston, MA 02129 USA Harvard Univ Boston MA USA 02129 achusetts Gen Hosp, Boston, MA 02129 USA Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA Harvard Univ Boston MA USA 02115 th, Dept Epidemiol, Boston, MA 02115 USA Massachusetts Mental Hlth Ctr, Harvard Inst Psychiat Epidemiol & Genet, Boston, MA 02115 USA Massachusetts Mental Hlth Ctr Boston MA USA 02115 t, Boston, MA 02115 USA
Titolo Testata:
CEREBRAL CORTEX
fascicolo: 6, volume: 11, anno: 2001,
pagine: 490 - 497
SICI:
1047-3211(200106)11:6<490:NSDOTA>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
GAMMA-AMINOBUTYRIC-ACID; RECEPTOR MESSENGER-RNA; HUMAN TEMPORAL CORTEX; HUMAN CEREBRAL-CORTEX; ESTROGEN-RECEPTORS; GENDER DIFFERENCES; MORPHOMETRIC ANALYSIS; INSITU HYBRIDIZATION; ANTERIOR COMMISSURE; HUMAN HYPOTHALAMUS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
78
Recensione:
Indirizzi per estratti:
Indirizzo: Goldstein, JM Massachusetts Mental Hlth Ctr, Harvard Inst Psychiat Epidemiol & Genet, 74Fenwood Rd, Boston, MA 02115 USA Massachusetts Mental Hlth Ctr 74 Fenwood Rd Boston MA USA 02115
Citazione:
J.M. Goldstein et al., "Normal sexual dimorphism of the adult human brain assessed by in vivo magnetic resonance imaging", CEREB CORT, 11(6), 2001, pp. 490-497

Abstract

The etiology and consistency of findings on normal sexual dimorphisms of the adult human brain are unresolved. In this study, we present a comprehensive evaluation of normal sexual dimorphisms of cortical and subcortical brain regions, using in vivo magnetic resonance imaging, in a community sampleof 48 normal adults. The men and women were similar in age, education, ethnicity, socioeconomic status, general intelligence and handedness. Forty-five brain regions were assessed based on T-1-weighted three-dimensional images acquired from a 1.5 T magnet. Sexual dimorphisms of adult brain volumes were more evident in the cortex, with women having larger volumes, relativeto cerebrum size, particularly in frontal and medial paralimbic cortices. Men had larger volumes, relative to cerebrum size, in frontomedial cortex, the amygdala and hypothalamus. A permutation test showed that, compared to other brain areas assessed in this study, there was greater sexual dimorphism among brain areas that are homologous with those identified in animal studies showing greater levels of sex steroid receptors during critical periods of brain development. These findings have implications for developmentalstudies that would directly test hypotheses about mechanisms relating sex steroid hormones to sexual dimorphisms in humans.

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Documento generato il 23/01/20 alle ore 12:27:40